Late‐stage Pd‐catalyzed Cyanations of Aryl/Heteroaryl Halides in Aqueous Micellar Media,ChemCatChem

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Late‐stage Pd‐catalyzed Cyanations of Aryl/Heteroaryl Halides in Aqueous Micellar Media
ChemCatChem ( IF 3.8 ) Pub Date : 2020-10-26 , DOI: 10.1002/cctc.202001742
Ruchita R. Thakore ₁ , Balaram S. Takale ₁ , Vani Singhania ₁ , Fabrice Gallou ₂ , Bruce H. Lipshutz ₁

Affiliation

New technology is described that enables late stage ppm Pd‐catalyzed cyanations of highly complex molecules, as well as a wide variety of aryl and heteroaryl halides possessing sensitive functional groups. These reactions are efficient in water containing nanomicelles, formed from a commercially available and inexpensive surfactant. The implications for advancing drug synthesis and discovery are apparent.

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