Quinone Methide‐Based Organophosphate Hydrolases Inhibitors: Trans Proximity Labelers versus Cis Labeling Activity‐Based Probes,ChemBioChem

当前位置： X-MOL 学术 › ChemBioChem › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Quinone Methide‐Based Organophosphate Hydrolases Inhibitors: Trans Proximity Labelers versus Cis Labeling Activity‐Based Probes
ChemBioChem ( IF 2.6 ) Pub Date : 2020-10-26 , DOI: 10.1002/cbic.202000611
Artem Dubovetskyi ₁ , Kesava Phaneendra Cherukuri ₁ , Yacov Ashani ₁ , Anna Meshcheriakova ₁ , Eitan Reuveny ₁ , Gili Ben-Nissan ₁ , Michal Sharon ₁ , Laura Fumagalli ₂ , Dan S Tawfik ₁

Affiliation

Internal affairs: Phosphoester substrates that release electrophilic quinone‐methides were applied as activity‐based probes in three phosphotriesterases that differ in mechanism and level of activity. Their substrates′ reactivity, and mode of labeling, were systematically investigated with the aim of achieving specific cis labeling rather than trans.

中文翻译：

基于醌甲基化物的有机磷酸酯水解酶抑制剂：Trans Proximity Labelers 与基于 Cis 标记活性的探针

内部事务：释放亲电子醌甲基化物的磷酸酯底物被用作三种不同机制和活性水平的磷酸三酯酶中的基于活性的探针。系统地研究了它们的底物反应性和标记模式，目的是实现特定的顺式标记而不是反式标记。

更新日期：2020-10-26

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南11