Graphene‐Based Biomaterials for Bone Regenerative Engineering: A Comprehensive Review of the Field and Considerations Regarding Biocompatibility and Biodegradation,Advanced Healthcare Materials

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Graphene‐Based Biomaterials for Bone Regenerative Engineering: A Comprehensive Review of the Field and Considerations Regarding Biocompatibility and Biodegradation
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2020-10-26 , DOI: 10.1002/adhm.202001414
Leila Daneshmandi _{1,

2,

3,

4} , Mohammed Barajaa _{1,

2,

3,

4} , Armin Tahmasbi Rad _{3,

5} , Stefanie A Sydlik _{6,

7} , Cato T Laurencin _{1,

2,

3,

4,

5,

8,

9}

Affiliation

Graphene and its derivatives have continued to garner worldwide interest due to their unique characteristics. Having expanded into biomedical applications, there have been efforts to employ their exceptional properties for the regeneration of different tissues, particularly bone. This article presents a comprehensive review on the usage of graphene‐based materials for bone regenerative engineering. The graphene family of materials (GFMs) are used either alone or in combination with other biomaterials in the form of fillers in composites, coatings for both scaffolds and implants, or vehicles for the delivery of various signaling and therapeutic agents. The applications of the GFMs in each of these diverse areas are discussed and emphasis is placed on the characteristics of the GFMs that have implications in this regard. In tandem and of importance, this article evaluates the safety and biocompatibility of the GFMs and carefully elucidates how various factors influence the biocompatibility and biodegradability of this new class of nanomaterials. In conclusion, the challenges and opportunities regarding the use of the GFMs in regenerative engineering applications are discussed, and future perspectives for the developments in this field are proposed.

中文翻译：

用于骨再生工程的石墨烯生物材料：生物相容性和生物降解领域的全面回顾和考虑

石墨烯及其衍生物因其独特的特性而持续引起全世界的关注。在扩展到生物医学应用领域后，人们一直在努力利用其卓越的特性来再生不同组织，特别是骨骼。本文对石墨烯基材料在骨再生工程中的应用进行了全面的综述。石墨烯材料家族（GFM）可以单独使用，也可以与其他生物材料组合使用，以复合材料中的填料、支架和植入物的涂层或用于输送各种信号和治疗剂的载体的形式使用。讨论了 GFM 在每个不同领域的应用，并重点讨论了在这方面具有影响的 GFM 的特征。同时重要的是，本文评估了 GFM 的安全性和生物相容性，并仔细阐明了各种因素如何影响此类新型纳米材料的生物相容性和生物降解性。总之，讨论了在再生工程应用中使用 GFM 的挑战和机遇，并提出了该领域的未来发展前景。

更新日期：2020-10-26

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