Designer, Programmable 3D DNA Nanodevices to Probe Biological Systems,ACS Applied Bio Materials

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Designer, Programmable 3D DNA Nanodevices to Probe Biological Systems
ACS Applied Bio Materials ( IF 4.6 ) Pub Date : 2020-10-26 , DOI: 10.1021/acsabm.0c00916
Anjali Rajwar ₁ , Sumit Kharbanda ₁ , Arun Richard Chandrasekaran ₂ , Sharad Gupta _{1,

3} , Dhiraj Bhatia _{1,

3}

Affiliation

DNA nanotechnology is a unique field that provides simple yet robust design techniques for self-assembling nanoarchitectures with extremely high potential for biomedical applications. Though the field began to exploit DNA to build various nanoscale structures, it has now taken a different path, diverging from the creation of complex structures to functional DNA nanodevices that explore various biological systems and mechanisms. Here, we present a brief overview of DNA nanotechnology, summarizing the key strategies for construction of various DNA nanodevices, with special focus on three-dimensional (3D) nanocages or polyhedras. We then discuss biological applications of 3D DNA nanocages, particularly tetrahedral DNA cages, in their ability to program and modulate cellular systems, in biosensing, and as tools for targeted therapeutics. We conclude with a final discussion on challenges and perspectives of 3D DNA nanodevices in biomedical applications.

中文翻译：

用于探测生物系统的可编程 3D DNA 纳米设备设计师

DNA 纳米技术是一个独特的领域，它为自组装纳米结构提供简单而强大的设计技术，具有极高的生物医学应用潜力。尽管该领域开始利用 DNA 来构建各种纳米级结构，但它现在走了一条不同的道路，从创建复杂结构到探索各种生物系统和机制的功能性 DNA 纳米装置。在这里，我们简要概述了 DNA 纳米技术，总结了构建各种 DNA 纳米器件的关键策略，特别关注三维 (3D) 纳米笼或多面体。然后，我们讨论了 3D DNA 纳米笼，特别是四面体 DNA 笼的生物学应用，它们在编程和调节细胞系统的能力、生物传感和靶向治疗工具方面的应用。

更新日期：2020-11-16

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