Stress is the main cause of mood disorders such as depression and posttraumatic stress disorder. Individuals respond to stress differently, as some develop depressive symptoms, whereas others successfully cope with adversity, but it remains unclear what makes some particularly vulnerable to stress. The chronic social defeat stress (CSDS) mouse model, an ethologically valid rodent model that exhibits long-term physiological and behavioral phenotypes similar to depression and anxiety, can imitate individual differences in stress responses in humans. In this review, we not only summarize various behavioral deficits of the CSDS mouse model that were reported since its establishment but also concentrate on modified CSDS mouse models that have been developed in recent years, aiming at providing useful information for future research and application of this model. (PsycInfo Database Record (c) 2020 APA, all rights reserved).

中文翻译：

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慢性社交失败压力小鼠模型：当前对其行为缺陷和修改的看法。

压力是情绪障碍的主要原因，例如抑郁症和创伤后应激障碍。个体对压力的反应不同，因为有些人会出现抑郁症状，而有些人则成功应对逆境，但尚不清楚是什么使某些人特别容易受到压力的影响。慢性社交失败压力 (CSDS) 小鼠模型是一种行为学上有效的啮齿动物模型，表现出类似于抑郁和焦虑的长期生理和行为表型，可以模仿人类应激反应的个体差异。在这篇综述中，我们不仅总结了 CSDS 小鼠模型自成立以来报告的各种行为缺陷，而且还专注于近年来开发的改良 CSDS 小鼠模型，旨在为该模型的未来研究和应用提供有用的信息。（PsycInfo 数据库记录 (c) 2020 APA，保留所有权利）。