Recent Advances in High-Throughput Automated Powder Dispensing Platforms for Pharmaceutical Applications,Organic Process Research & Development

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Recent Advances in High-Throughput Automated Powder Dispensing Platforms for Pharmaceutical Applications
Organic Process Research & Development ( IF 3.1 ) Pub Date : 2020-10-23 , DOI: 10.1021/acs.oprd.0c00411
Matthew N. Bahr ₁ , Mark A. Morris ₂ , Noah P. Tu ₃ , Aakankschit Nandkeolyar _{1,

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Affiliation

A wide array of pharmaceutical research studies involve dispensing a variety of powders such as active ingredients, intermediates, catalysts, and formulation excipients. Automated powder dispensing platforms are increasingly relied upon to perform the mundane task of filling vials in multi-well plates for high-throughput experimentation workflows. A small group of pharmaceutical scientists collaborated to evaluate recent advances in commercially available automation platforms from two instrument manufacturers using previously reported objective and systematic testing protocols. This manuscript details the testing conditions used for the evaluation and the results obtained and assesses the impact that the powder characteristics had on the performance of the selected platforms through statistical analysis.

中文翻译：

用于制药应用的高通量自动粉末分配平台的最新进展

广泛的药物研究涉及分配各种粉末，例如活性成分，中间体，催化剂和制剂赋形剂。越来越多地依赖自动粉末分配平台执行将小瓶填充到多孔板中的常规任务，以进行高通量实验工作流程。一小组药物科学家使用先前报告的客观和系统测试协议，合作评估了两家仪器制造商在商用自动化平台上的最新进展。该手稿详细介绍了用于评估的测试条件和获得的结果，并通过统计分析评估了粉末特性对所选平台性能的影响。

更新日期：2020-11-21

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