Progress in Natural Compounds/siRNA Co-delivery Employing Nanovehicles for Cancer Therapy,ACS Combinatorial Science

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Progress in Natural Compounds/siRNA Co-delivery Employing Nanovehicles for Cancer Therapy
ACS Combinatorial Science Pub Date : 2020-10-23 , DOI: 10.1021/acscombsci.0c00099
Milad Ashrafizadeh _{1,

2} , Ali Zarrabi ₂ , Kiavash Hushmandi ₃ , Farid Hashemi ₄ , Ebrahim Rahmani Moghadam ₅ , Mehdi Raei ₆ , Mahshad Kalantari ₇ , Shima Tavakol ₈ , Reza Mohammadinejad ₉ , Masoud Najafi _{10,

11} , Franklin R Tay ₁₂ , Pooyan Makvandi _{13,

14}

Affiliation

Faculty of Engineering and Natural Sciences, Sabanci University, Orta Mahalle, Üniversite Caddesi No. 27, Orhanlı, Tuzla, 34956 Istanbul, Turkey.
Sabanci University Nanotechnology Research and Application Center (SUNUM), Tuzla 34956, Istanbul Turkey.
Department of Food Hygiene and Quality Control, Division of Epidemiology & Zoonoses, Faculty of Veterinary Medicine, University of Tehran, Tehran 1419963114, Iran.
Department of Comparative Biosciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.
Department of Anatomical Sciences, School of Medicine, Student Research Committee, Shiraz University of Medical Sciences, Shiraz 7134814336, Iran.
Health Research Center, Life Style Institute, Baqiyatallah University of Medical Sciences, Tehran 1435916471, Iran.
Department of Genetics, Tehran Medical Sciences Branch, Azad University, Tehran 19168931813, Iran.
Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran 1449614525, Iran.
Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman 7616911319, Iran.
Medical Technology Research Center, Institute of Health Technology, Kermanshah University of Medical Sciences, Kermanshah 6715847141, Iran.
Radiology and Nuclear Medicine Department, School of Paramedical Sciences, Kermanshah University of Medical Sciences, Kermanshah 6715847141, Iran.
College of Graduate Studies, Augusta University, Augusta, Georgia 30912, United States.
Istituto Italiano di Tecnologia, Centre for Micro-BioRobotics, viale Rinaldo Piaggio 34, 56025 Pontedera, Pisa Italy.
Department of Medical Nanotechnology, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, 14496-14535 Tehran, Iran.

Chemotherapy using natural compounds, such as resveratrol, curcumin, paclitaxel, docetaxel, etoposide, doxorubicin, and camptothecin, is of importance in cancer therapy because of the outstanding therapeutic activity and multitargeting capability of these compounds. However, poor solubility and bioavailability of natural compounds have limited their efficacy in cancer therapy. To circumvent this hurdle, nanocarriers have been designed to improve the antitumor activity of the aforementioned compounds. Nevertheless, cancer treatment is still a challenge, demanding novel strategies. It is well-known that a combination of natural products and gene therapy is advantageous over monotherapy. Delivery of multiple therapeutic agents/small interfering RNA (siRNA) as a potent gene-editing tool in cancer therapy can maximize the synergistic effects against tumor cells. In the present review, co-delivery of natural compounds/siRNA using nanovehicles are highlighted to provide a backdrop for future research.

中文翻译：

利用纳米载体进行天然化合物/siRNA 联合递送用于癌症治疗的进展

使用天然化合物（例如白藜芦醇、姜黄素、紫杉醇、多西紫杉醇、依托泊苷、阿霉素和喜树碱）的化疗在癌症治疗中具有重要意义，因为这些化合物具有出色的治疗活性和多靶点能力。然而，天然化合物的溶解度和生物利用度较差，限制了其在癌症治疗中的功效。为了克服这个障碍，纳米载体被设计来提高上述化合物的抗肿瘤活性。尽管如此，癌症治疗仍然是一个挑战，需要新的策略。众所周知，天然产物和基因疗法的结合比单一疗法更有优势。递送多种治疗剂/小干扰RNA (siRNA) 作为癌症治疗中有效的基因编辑工具，可以最大限度地发挥针对肿瘤细胞的协同效应。在本综述中，重点介绍了使用纳米载体共同递送天然化合物/siRNA，为未来的研究提供背景。

更新日期：2020-12-14

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