Application of Hydrogel-Based Delivery System in Endometrial Repair,ACS Applied Bio Materials

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Application of Hydrogel-Based Delivery System in Endometrial Repair
ACS Applied Bio Materials ( IF 4.6 ) Pub Date : 2020-10-23 , DOI: 10.1021/acsabm.0c00971
Yifeng Lin ₁ , Shunni Dong ₂ , Wei Zhao ₃ , Kai-Lun Hu ₁ , Juan Liu ₁ , Siwen Wang ₁ , Mixue Tu ₁ , Binyang Du ₂ , Dan Zhang _{1,

3}

Affiliation

A receptive endometrium with proper thickness is essential for successful embryo implantation. However, endometrial injury caused by intrauterine procedures often leads to pathophysiological changes in its environment, resulting in subsequent female infertility. Among diverse treatment methods of endometrial injury, hydrogels are a class of hydrophilic three-dimensional polymeric network with biocompatibility as well as the capability of absorbing water and encapsulation, which have potential applications as a promising intrauterine controlled-release delivery system. This review summarizes recent advances in the approaches of endometrial repair and further focuses on the application of a hydrogel-based delivery system in endometrial repair, including its preparation, therapeutic loading considerations, clinical applications, as well as working mechanisms.

中文翻译：

基于水凝胶的输送系统在子宫内膜修复中的应用

具有适当厚度的容受性子宫内膜对于成功的胚胎植入至关重要。然而，宫内手术引起的子宫内膜损伤往往会导致其环境发生病理生理变化，从而导致随后的女性不育。在多种子宫内膜损伤治疗方法中，水凝胶是一类亲水性三维聚合物网络，具有生物相容性以及吸水和包封能力，作为一种有前途的宫内控释给药系统具有潜在的应用前景。本综述总结了子宫内膜修复方法的最新进展，并进一步关注基于水凝胶的递送系统在子宫内膜修复中的应用，包括其制备、治疗负荷考虑、临床应用、

更新日期：2020-11-16

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