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On-Demand and Long-Term Drug Delivery from Degradable Nanocapsules
ACS Applied Bio Materials ( IF 4.6 ) Pub Date : 2020-10-23 , DOI: 10.1021/acsabm.0c01130 Sydney Menikheim 1 , Joshua Leckron 1 , Steven Bernstein 2 , Erin B Lavik 1
ACS Applied Bio Materials ( IF 4.6 ) Pub Date : 2020-10-23 , DOI: 10.1021/acsabm.0c01130 Sydney Menikheim 1 , Joshua Leckron 1 , Steven Bernstein 2 , Erin B Lavik 1
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We have developed polyurethane nanocapsules as a platform for long-term delivery of drugs over weeks as well as on-demand delivery of drugs via ultrasound. We synthesized nanocapsules encapsulating either a model drug, fluorescein, or a clinically relevant drug, acriflavine, a HIF-1alpha inhibitor. Release studies demonstrated delivery of fluorescein or acriflavine over several weeks. Application of either an ultrasonic probe or a clinical grade, ultrasound imaging system used for assessing the retina led to release of a fraction of drug that could be tailored by the energy applied to the nanocapsules, and multiple pulses of release could be triggered over time with at least 10 separate release events triggered for each formulation. Being able to tailor the on-demand release over multiple cycles has the potential to fundamentally change how we can approach delivery of drugs for a variety of applications.
中文翻译：
可降解纳米胶囊的按需和长期药物输送
我们开发了聚氨酯纳米胶囊作为平台，可在数周内长期输送药物，以及通过超声波按需输送药物。我们合成了封装模型药物荧光素或临床相关药物吖啶黄（一种 HIF-1α 抑制剂）的纳米胶囊。释放研究表明荧光素或吖啶黄素在数周内的释放。用于评估视网膜的超声探头或临床级超声成像系统的应用导致释放一小部分药物，这些药物可以通过施加到纳米胶囊的能量进行定制，并且随着时间的推移可以触发多个释放脉冲每个配方至少触发 10 个单独的释放事件。
更新日期：2020-11-16
中文翻译：
可降解纳米胶囊的按需和长期药物输送
我们开发了聚氨酯纳米胶囊作为平台，可在数周内长期输送药物，以及通过超声波按需输送药物。我们合成了封装模型药物荧光素或临床相关药物吖啶黄（一种 HIF-1α 抑制剂）的纳米胶囊。释放研究表明荧光素或吖啶黄素在数周内的释放。用于评估视网膜的超声探头或临床级超声成像系统的应用导致释放一小部分药物，这些药物可以通过施加到纳米胶囊的能量进行定制，并且随着时间的推移可以触发多个释放脉冲每个配方至少触发 10 个单独的释放事件。
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