Single‐cell analysis identified lung progenitor cells in COVID‐19 patients,Cell Proliferation

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Single‐cell analysis identified lung progenitor cells in COVID‐19 patients
Cell Proliferation ( IF 5.9 ) Pub Date : 2020-10-22 , DOI: 10.1111/cpr.12931
Zixian Zhao ₁ , Yu Zhao ₁ , Yueqing Zhou ₁ , Xiaofan Wang ₁ , Ting Zhang ₂ , Wei Zuo ₁

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The high mortality of severe 2019 novel coronavirus disease (COVID‐19) cases is mainly caused by acute respiratory distress syndrome (ARDS), which is characterized by increased permeability of the alveolar epithelial barriers, pulmonary oedema and consequently inflammatory tissue damage. Some but not all patients showed full functional recovery after the devastating lung damage, and so far there is little knowledge about the lung repair process. We focused on crucial roles of lung progenitor cells in alveolar cell regeneration and epithelial barrier re‐establishment and aimed to uncover a possible mechanism of lung repair after severe SARS‐CoV‐2 infection.

中文翻译：

单细胞分析确定了 COVID-19 患者的肺祖细胞

严重的 2019 新型冠状病毒病 (COVID-19) 病例的高死亡率主要是由急性呼吸窘迫综合征 (ARDS) 引起的，其特征是肺泡上皮屏障通透性增加、肺水肿和炎症组织损伤。一些但并非所有患者在毁灭性肺损伤后都显示出完全的功能恢复，到目前为止，对肺修复过程知之甚少。我们专注于肺祖细胞在肺泡细胞再生和上皮屏障重建中的关键作用，旨在揭示严重 SARS-CoV-2 感染后肺修复的可能机制。

更新日期：2020-10-22

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