Effectiveness of Photobiomodulation as an Adjunct to Non‐surgical Periodontal Therapy in the Management of Periodontitis‐ A Systematic Review of in vivo Human Studies,Photochemistry and Photobiology

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Effectiveness of Photobiomodulation as an Adjunct to Non‐surgical Periodontal Therapy in the Management of Periodontitis‐ A Systematic Review of in vivo Human Studies
Photochemistry and Photobiology ( IF 2.6 ) Pub Date : 2020-11-12 , DOI: 10.1111/php.13348
Snehal Dalvi _{1,

2} , Stefano Benedicenti ₁ , Reem Hanna _{1,

3}

Affiliation

Photobiomodulation therapy (PBMT) has anti-inflammatory, analgesic and regenerative properties. This systematic review aimed to critically appraise the published data of in vivo human randomized clinical trials (RCTs), and present a comprehensive overview of the efficacy of PBMT, as an adjunct to the non-surgical periodontal therapy (NSPT) in the management of periodontitis. The systematic review protocol is registered in the Prospective Register Of Systematic Reviews (PROSPERO) (www.crd.york.ac.uk/PROSPERO/; ref CRD 42020169108). With the help of the appropriate key words, structured electronic and manual search strategies were applied to gather the relevant published data on in vivo human RCTs based on this topic. Seventeen papers that met the eligibility criteria were included in this review and subjected to a qualitative assessment. Current evidence lacks adequate information regarding the photobiomodulation (PBM) dosimetry, which is fundamental in establishing a standardized and replicable protocol for future researches. Furthermore, substantial discrepancies in the study methodology and a high risk of bias, arising from the majority of the included papers, abet to the inferior quality of these studies. Ultimately, there is an urgent necessity to conduct further well-designed RCTs in order to determine the effectiveness of PBMT, if any, by taking into consideration the abovementioned confounding factors.

中文翻译：

光生物调节作为非手术牙周治疗辅助治疗牙周炎的有效性——对体内人体研究的系统评价

光生物调节疗法 (PBMT) 具有抗炎、镇痛和再生特性。本系统评价旨在批判性评估已发表的体内人体随机临床试验 (RCT) 数据，并全面概述 PBMT 作为非手术牙周治疗 (NSPT) 治疗牙周炎的辅助手段. 系统评价方案已在系统评价前瞻性登记册 (PROSPERO) 中注册（www.crd.york.ac.uk/PROSPERO/；参考 CRD 42020169108）。借助适当的关键词，应用结构化的电子和手动搜索策略来收集基于该主题的体内人类 RCT 的相关已发表数据。符合资格标准的 17 篇论文被纳入本次审查并进行定性评估。目前的证据缺乏关于光生物调节 (PBM) 剂量学的足够信息，这对于为未来的研究建立标准化和可复制的协议至关重要。此外，研究方法的巨大差异和大多数纳入论文产生的高偏倚风险助长了这些研究的质量低下。最终，迫切需要进行进一步精心设计的 RCT，以便通过考虑上述混杂因素来确定 PBMT（如果有的话）的有效性。来自大多数纳入的论文，助长了这些研究的质量低下。最终，迫切需要进行进一步精心设计的 RCT，以便通过考虑上述混杂因素来确定 PBMT（如果有的话）的有效性。来自大多数纳入的论文，助长了这些研究的质量低下。最终，迫切需要进行进一步精心设计的 RCT，以便通过考虑上述混杂因素来确定 PBMT（如果有的话）的有效性。

更新日期：2020-11-12

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