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Structures of ABC transporters: handle with care
FEBS Letters ( IF 3.0 ) Pub Date : 2020-11-21 , DOI: 10.1002/1873-3468.13966
Oded Lewinson 1 , Cédric Orelle 2 , Markus A Seeger 3
Affiliation  

In the past two decades, the ATP‐binding cassette (ABC) transporters' field has undergone a structural revolution. The importance of structural biology to the development of the field of ABC transporters cannot be overstated, as the ensemble of structures not only revealed the architecture of ABC transporters but also shaped our mechanistic view of these remarkable molecular machines. Nevertheless, we advocate that the mechanistic interpretation of the structures is not trivial and should be carried out with prudence. Herein, we bring several examples of structures of ABC transporters that merit re‐interpretation via careful comparison to experimental data. We propose that it is of the upmost importance to place new structures within the context of the available experimental data.

中文翻译:

ABC运输车的结构:小心处理

在过去的二十年中,ATP 结合盒 (ABC) 转运蛋白领域经历了一场结构革命。结构生物学对 ABC 转运蛋白领域发展的重要性怎么强调都不为过,因为结构的集合不仅揭示了 ABC 转运蛋白的结构,而且还塑造了我们对这些非凡分子机器的机械观点。尽管如此,我们主张对结构的机械解释并非微不足道,应谨慎进行。在这里,我们提供了几个 ABC 转运蛋白结构的例子,这些例子值得通过与实验数据的仔细比较来重新解释。我们建议将新结构置于可用实验数据的背景下是最重要的。
更新日期:2020-11-21
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