当前位置：
X-MOL 学术
›
Clin. Transl. Immunol.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Blockade of IL‐33 signalling attenuates osteoarthritis
Clinical & Translational Immunology ( IF 4.6 ) Pub Date : 2020-10-23 , DOI: 10.1002/cti2.1187 Zengliang He 1 , Yan Song 1 , Yongxiang Yi 2 , Fengzhuo Qiu 3 , Junhua Wang 4 , Junwei Li 4 , Qingwen Jin 3 , Pradeep Kumar Sacitharan 5, 6
Clinical & Translational Immunology ( IF 4.6 ) Pub Date : 2020-10-23 , DOI: 10.1002/cti2.1187 Zengliang He 1 , Yan Song 1 , Yongxiang Yi 2 , Fengzhuo Qiu 3 , Junhua Wang 4 , Junwei Li 4 , Qingwen Jin 3 , Pradeep Kumar Sacitharan 5, 6
Affiliation
|
Osteoarthritis (OA) is the most common form of arthritis characterised by cartilage degradation, synovitis and pain. Disease modifying treatments for OA are not available. The critical unmet need is to find therapeutic targets to reduce both disease progression and pain. The cytokine IL‐33 and its receptor ST2 have been shown to play a role in immune and inflammatory diseases, but their role in osteoarthritis is unknown.
中文翻译：
阻断 IL-33 信号传导可减轻骨关节炎
骨关节炎 (OA) 是最常见的关节炎形式，其特征是软骨退化、滑膜炎和疼痛。OA 的疾病改善治疗不可用。关键的未满足需求是找到减少疾病进展和疼痛的治疗靶点。细胞因子 IL-33 及其受体 ST2 已被证明在免疫和炎症疾病中发挥作用，但它们在骨关节炎中的作用尚不清楚。
更新日期：2020-10-26
中文翻译：
阻断 IL-33 信号传导可减轻骨关节炎
骨关节炎 (OA) 是最常见的关节炎形式，其特征是软骨退化、滑膜炎和疼痛。OA 的疾病改善治疗不可用。关键的未满足需求是找到减少疾病进展和疼痛的治疗靶点。细胞因子 IL-33 及其受体 ST2 已被证明在免疫和炎症疾病中发挥作用，但它们在骨关节炎中的作用尚不清楚。
京公网安备 11010802027423号