Use of critically important antimicrobial classes early in life may adversely impact bacterial resistance profiles during adult years: potential co‐selection for plasmid‐borne fluoroquinolone and macrolide resistance via extended‐spectrum beta‐lactam use in dairy cattle,Letters in Applied Microbiology

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Use of critically important antimicrobial classes early in life may adversely impact bacterial resistance profiles during adult years: potential co‐selection for plasmid‐borne fluoroquinolone and macrolide resistance via extended‐spectrum beta‐lactam use in dairy cattle
Letters in Applied Microbiology ( IF 2.0 ) Pub Date : 2020-11-20 , DOI: 10.1111/lam.13419
E.A. Taylor ₁ , C. Ossa‐Trujillo _{1,

2} , J. Vinasco ₁ , E.R. Jordan ₃ , J.A. García Buitrago ₄ , R. Hagevoort ₄ , K.N. Norman ₅ , S.D. Lawhon ₁ , J.M. Piñeiro ₆ , G. Levent ₁ , H.M. Scott ₁

Affiliation

The transfer of antimicrobial resistance genes commonly occurs via vertical and horizontal gene transfer, as such genes are often found on the same mobile genetic element. This occurrence can lead to the co-selection of resistance to antimicrobials without their application. Dairy cattle located in the southwestern United States were enrolled in a matched-pair longitudinal study to evaluate the effects of a two-dose ceftiofur treatment for metritis on levels of third-generation cephalosporin resistance among faecal Escherichia coli temporally. E. coli chosen for further investigation were isolated on selective media, harboured extended-spectrum beta-lactamase, fluoroquinolone, and macrolide resistance genes. This combination has previously been unreported; importantly, it included genes encoding for resistance to antibiotics that can only be used in dairy cattle less than 20 months of age. Fluoroquinolones, macrolides and third and greater generation cephalosporins are considered critically important and highest priority for human medicine by the World Health Organization.

中文翻译：

在生命早期使用极其重要的抗菌药物类别可能会对成年后的细菌耐药性产生不利影响：通过在奶牛中使用广谱 β-内酰胺对质粒携带的氟喹诺酮类药物和大环内酯类药物耐药性的潜在共同选择

抗菌素抗性基因的转移通常通过垂直和水平基因转移发生，因为这些基因通常存在于相同的移动遗传元件上。这种情况会导致对抗微生物剂的抗性的共同选择，而不应用它们。位于美国西南部的奶牛参加了一项配对纵向研究，以评估两剂头孢噻呋治疗子宫炎对粪便大肠杆菌中第三代头孢菌素耐药性水平的影响。选择用于进一步研究的大肠杆菌在选择性培养基上分离，含有超广谱 β-内酰胺酶、氟喹诺酮和大环内酯抗性基因。这种组合以前没有报道过；重要的，它包括编码抗生素抗性的基因，这些基因只能用于小于 20 个月大的奶牛。氟喹诺酮类、大环内酯类和第三代及以上的头孢菌素被世界卫生组织认为是人类医学中极其重要和最优先的药物。

更新日期：2020-11-20

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