Diabetes impairs insulin‐induced endothelium‐dependent relaxation by reducing nitric oxide (NO) production. GLP‐1, an incretin hormone, has been shown to prevent the development of endothelial dysfunction. In this study, we hypothesized that GLP‐1 would improve the impaired insulin‐induced relaxation response in diabetic mice. We also examined the underlying mechanisms.

中文翻译：

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GLP-1 通过 β-arrestin2 调节糖尿病小鼠主动脉来调节胰岛素诱导的舒张反应

糖尿病通过减少一氧化氮 (NO) 的产生来损害胰岛素诱导的内皮依赖性舒张。GLP-1 是一种肠促胰岛素激素，已被证明可以防止内皮功能障碍的发展。在这项研究中，我们假设 GLP-1 会改善糖尿病小鼠受损的胰岛素诱导的松弛反应。我们还研究了潜在的机制。