Increased interest in the field of tissue engineering promotes the development of biomaterial design. Aspiration to reconstruct native extracellular matrix architecture (ECM) expands the number of applying approaches in polymer scaffold development. In the present work, we proposed a combination of electrospinning and lyophilization techniques to produce materials with ECM‐like morphology based on poly‐l‐lactide fiber matrix with natural bio‐adequate fillers (collagen and chitosan). Morphology, mechanical properties, and hydrophilicity of the developed biomaterials were studied. The introduction of the collagen filler enhanced the strength and Young's modulus of the composites by 190% and 80%. The same characteristics of the chitosan‐containing material were increased by 430% and 340%, respectively. It exceeded the collagen ones, which was caused by the better chitosan penetration into the fiber matrix and, as a result, the percolation network formation. The possibility of material wettability improving was shown.

中文翻译：

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含壳聚糖和胶原蛋白的高多孔聚丙交酯基复合材料的研究

对组织工程领域的兴趣增加，促进了生物材料设计的发展。重建天然细胞外基质结构（ECM）的愿望扩大了聚合物支架开发中的应用方法。在目前的工作中，我们提出了样ECM形态基于聚电纺丝和冻干技术，生产材料的组合升丙交酯纤维基质与天然生物充足填料（胶原蛋白和壳聚糖）。研究了已开发生物材料的形态，力学性能和亲水性。胶原填充剂的引入使复合材料的强度和杨氏模量分别提高了190％和80％。含壳聚糖的材料的相同特性分别提高了430％和340％。它超过了胶原蛋白，这是由于壳聚糖更好地渗透到纤维基质中，因此形成了渗滤网络。显示了材料润湿性提高的可能性。