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Electrospun progesterone‐loaded cellulose acetate nanofibers and their drug sustained‐release profiles
Polymer Engineering and Science ( IF 3.2 ) Pub Date : 2020-10-22 , DOI: 10.1002/pen.25549 Gabriella Onila do Nascimento Soares 1 , Raíssa Ribeiro Lima Machado 2 , Mariana Mendonça Diniz 2 , Aline Bruna da Silva 2
Polymer Engineering and Science ( IF 3.2 ) Pub Date : 2020-10-22 , DOI: 10.1002/pen.25549 Gabriella Onila do Nascimento Soares 1 , Raíssa Ribeiro Lima Machado 2 , Mariana Mendonça Diniz 2 , Aline Bruna da Silva 2
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Novel cellulose acetate (CA) nanofibers incorporated with hormone progesterone (P4) were prepared by electrospinning and its potential as a controlled release system for medicine and veterinary was evaluated by controlled release essay. The morphology, thermal behavior, and structure of P4‐loaded CA nanofibers were characterized by scanning electron microscopy, differential scanning calorimetry, and Fourier‐transform infrared spectroscopy. The analyses revealed that the incorporation of P4 increased nanofibers' diameter from around 340 to 892 nm to 8% w/w P4‐loaded CA nanofibers. Furthermore, P4 has demonstrated high interaction with CA affecting its crystalline structure, since pure CA nanofibers presented 67.23% of crystallinity while P4‐loaded CA nanofibers where amorphous. Ultimately, the drug release essay demonstrated a two‐stage profile, and regarding release kinetics, the samples evidenced a diffusion mechanism depending on P4 concentration in the nanofiber.
中文翻译：
电纺黄体酮醋酸纤维素纳米纤维及其药物缓释曲线
通过静电纺丝制备了结合有激素孕酮（P 4）的新型醋酸纤维素（CA）纳米纤维，并通过控释论文评估了其作为药物和兽药控释系统的潜力。通过扫描电子显微镜，差示扫描量热法和傅里叶变换红外光谱法表征了负载P 4的CA纳米纤维的形态，热行为和结构。分析表明，P 4的掺入将纳米纤维的直径从大约340纳米增加到892 nm，增加了8％w / w的P 4负载的CA纳米纤维。此外，P 4由于纯CA纳米纤维呈现67.23％的结晶度，而P 4负载的CA纳米纤维则是无定形的，因此已证明与CA的相互作用会影响其晶体结构。最终，药物释放论文显示了两个阶段的概况，并且关于释放动力学，样品证明了取决于纳米纤维中P 4浓度的扩散机制。
更新日期：2020-12-14
中文翻译：
电纺黄体酮醋酸纤维素纳米纤维及其药物缓释曲线
通过静电纺丝制备了结合有激素孕酮（P 4）的新型醋酸纤维素（CA）纳米纤维，并通过控释论文评估了其作为药物和兽药控释系统的潜力。通过扫描电子显微镜，差示扫描量热法和傅里叶变换红外光谱法表征了负载P 4的CA纳米纤维的形态，热行为和结构。分析表明，P 4的掺入将纳米纤维的直径从大约340纳米增加到892 nm，增加了8％w / w的P 4负载的CA纳米纤维。此外，P 4由于纯CA纳米纤维呈现67.23％的结晶度，而P 4负载的CA纳米纤维则是无定形的，因此已证明与CA的相互作用会影响其晶体结构。最终，药物释放论文显示了两个阶段的概况，并且关于释放动力学，样品证明了取决于纳米纤维中P 4浓度的扩散机制。
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