Fungal infections are responsible for high mortality rates in immunocompromised and high-risk surgical patients. Therapy failures during the last decades due to increasing multidrug resistance demand innovative strategies for novel and effective antifungal drugs. Synergistic combinations of antifungals with non-antifungal agents highlight a pragmatic strategy to reduce the development of drug resistance and potentially repurpose known compounds with other functions to bypass costly and time-consuming novel drug development.

中文翻译：

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真菌感染的替代治疗：与非抗真菌药物的协同作用

真菌感染导致免疫功能低下和高危手术患者的高死亡率。在过去几十年中，由于多药耐药性增加而导致的治疗失败需要针对新型有效抗真菌药物的创新策略。抗真菌剂与非抗真菌剂的协同组合突出了一种务实的策略，以减少耐药性的发展，并可能重新利用具有其他功能的已知化合物来绕过昂贵且耗时的新药开发。