Advances in Exosomes‐Based Drug Delivery Systems,Macromolecular Bioscience

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Advances in Exosomes‐Based Drug Delivery Systems
Macromolecular Bioscience ( IF 4.4 ) Pub Date : 2020-10-22 , DOI: 10.1002/mabi.202000269
Carmen Gutierrez-Millan _{1,

2} , Clara Calvo Díaz ₁ , José M Lanao _{1,

2} , Clara I Colino _{1,

2}

Affiliation

Exosomes, a subgroup of extracellular vesicles, are important mediators of long‐distance intercellular communication and are involved in a diverse range of biological processes such as the transport of lipids, proteins, and nucleic acids. Researchers, seeing the problems caused by the toxic effects and clearance of synthetic nanoparticles, consider exosomes as an interesting alternative to such nanoparticles in the specific and controlled transport of drugs. In recent years, there have been remarkable advances in the use of exosomes in cancer therapeutics or for treating neurological diseases, among other applications. The objective of this work is to analyze studies focused on exosomes used in drug delivery system, present and future applications in this field of research are discussed based on the results obtained.

中文翻译：

基于外泌体的药物递送系统的进展

外泌体是细胞外囊泡的一个亚群，是长距离细胞间通讯的重要介质，参与多种生物过程，如脂质、蛋白质和核酸的转运。研究人员看到由合成纳米颗粒的毒性作用和清除引起的问题，认为外泌体是此类纳米颗粒在药物特定和受控运输中的有趣替代品。近年来，外泌体在癌症治疗或神经系统疾病等应用中的应用取得了显着进展。这项工作的目的是分析专注于药物递送系统中使用的外泌体的研究，并根据获得的结果讨论该研究领域的当前和未来应用。

更新日期：2020-10-22

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