Differential alterations of insular cortex excitability after adolescent or adult chronic intermittent ethanol administration in male rats,Journal of Neuroscience Research

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Differential alterations of insular cortex excitability after adolescent or adult chronic intermittent ethanol administration in male rats
Journal of Neuroscience Research ( IF 2.9 ) Pub Date : 2020-10-22 , DOI: 10.1002/jnr.24737
Yi-Xiao Luo _{1,

2} , Ewa Galaj ₂ , Yao-Ying Ma _{1,

2,

3}

Affiliation

Adolescent alcohol drinking, primarily in the form of binge‐drinking episodes, is a serious public health concern. Binge drinking in laboratory animals has been modeled by a procedure involving chronic intermittent ethanol (CIE) administration, as compared with chronic intermittent water (CIW). The prolonged effects of adolescent binge alcohol exposure in adults, such as high risk of developing alcohol use disorder, are severe but available treatments in the clinic are limited. One reason is the lack of sufficient understanding about the associated neuronal alterations. The involvement of the insular cortex, particularly the anterior agranular insula (AAI), has emerged as a critical region to explain neuronal mechanisms of substance abuse. This study was designed to evaluate the functional output of the AAI by measuring the intrinsic excitability of pyramidal neurons from male rats 2 or 21 days after adolescent or adult CIE treatment. Decreases in intrinsic excitability in AAI pyramidal neurons were detected 21 days, relative to 2 days, after adolescent CIE. Interestingly, the decreased intrinsic excitability in the AAI pyramidal neurons was observed 2 days after adult CIE, compared to adult CIW, but no difference was found between 2 versus 21 days after adult CIE. These data indicate that, although the AAI is influenced within a limited period after adult but not adolescent CIE, neuronal alterations in AAI are affected during the prolonged period of withdrawal from adolescent but not adult CIE. This may explain the prolonged vulnerability to mental disorders of subjects with an alcohol binge history during their adolescent stage.

中文翻译：

雄性大鼠青少年或成人慢性间歇乙醇给药后岛叶皮质兴奋性的差异变化

青少年饮酒，主要以暴饮暴食的形式出现，是一个严重的公共卫生问题。与慢性间歇性饮水 (CIW) 相比，实验室动物的暴饮暴食已通过涉及慢性间歇性乙醇 (CIE) 给药的程序进行建模。青少年酗酒对成年人的长期影响，例如患酒精使用障碍的高风险，是严重的，但临床上可用的治疗方法有限。原因之一是对相关的神经元改变缺乏足够的了解。岛叶皮层的参与，特别是前无颗粒岛叶 (AAI)，已成为解释药物滥用的神经元机制的关键区域。本研究旨在通过测量青少年或成人 CIE 治疗后 2 或 21 天雄性大鼠锥体神经元的内在兴奋性来评估 AAI 的功能输出。在青少年 CIE 后 21 天（相对于 2 天）检测到 AAI 锥体神经元的内在兴奋性降低。有趣的是，与成人 CIW 相比，在成人 CIE 后 2 天观察到 AAI 锥体神经元的内在兴奋性降低，但在成人 CIE 后 2 天与 21 天之间没有发现差异。这些数据表明，虽然 AAI 在成人而非青少年 CIE 后的有限时间内受到影响，但在从青少年而非成人 CIE 退出的延长期间，AAI 的神经元改变会受到影响。

更新日期：2020-12-20

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