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Cyclodextrin glycosyltransferase‐treated germinated brown rice flour improves the cytotoxic capacity of HepG2 cell and has a positive effect on type‐2 diabetic mice
Journal of Food Biochemistry ( IF 3.5 ) Pub Date : 2020-10-22 , DOI: 10.1111/jfbc.13533 Nguyen Duong Thanh Binh 1 , Nguyen Thi Le Ngoc 1 , Ibitoye Joshua Oladapo 1 , Co Hong Son 2 , Do Thi Thao 3 , Dai Thi Xuan Trang 4 , Tong Thi Anh Ngoc 1 , Nguyen Cong Ha 1
Journal of Food Biochemistry ( IF 3.5 ) Pub Date : 2020-10-22 , DOI: 10.1111/jfbc.13533 Nguyen Duong Thanh Binh 1 , Nguyen Thi Le Ngoc 1 , Ibitoye Joshua Oladapo 1 , Co Hong Son 2 , Do Thi Thao 3 , Dai Thi Xuan Trang 4 , Tong Thi Anh Ngoc 1 , Nguyen Cong Ha 1
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Germinated brown rice (GBR) consists of bioactive compounds (BCs) that are very useful for diabetes treatment. Modified GBR‐based flour (MGBRF) was produced by modifying the starch in GBR with 0, 299.19, 598.38, and 897.57 U/ml of cyclodextrin glycosyltransferase (CGTase) for 1 hr and then spray‐dried to examine its antidiabetic and cytotoxic effects. The results showed that the slowly digestible starch and resistant starch by modifying the starch in GBR with 598.38 U/ml of CGTase were 55.8% and 5.92% corresponding to the increase of γ‐amino butyric acid (GABA) and ferulic acid (FA) with 4.31 ± 0.68 mg/ml and 3.10 ± 0.02 mg/ml, respectively. The extract from MGBRF showed strong cytotoxic capacity against HepG2. Furthermore, the in vivo study revealed the stability of the glycemic index (GI) by consuming MGBRF with significant impacts on diabetes. These results suggest that MGBRF through the action of CGTase plays a major role in antidiabetes and HepG2 cell product value addition.
中文翻译：
环糊精糖基转移酶处理的发芽糙米粉可提高HepG2细胞的细胞毒性能力，并对2型糖尿病小鼠产生积极影响
发芽糙米（GBR）由对糖尿病治疗非常有用的生物活性化合物（BCs）组成。经过修饰的基于GBR的面粉（MGBRF）是通过用0、299.19、598.38和897.57 U / ml的环糊精糖基转移酶（CGTase）修饰GBR中的淀粉1小时后喷雾干燥以检查其抗糖尿病和细胞毒性作用而生产的。结果表明，用598.38 U / ml CGTase修饰GBR中的慢消化淀粉和抗性淀粉分别为55.8％和5.92％，分别与γ-氨基丁酸（GABA）和阿魏酸（FA）的增加有关。分别为4.31±0.68 mg / ml和3.10±0.02 mg / ml。MGBRF的提取物显示出对HepG2的强大细胞毒性能力。此外，体内研究显示，通过摄入对糖尿病有重大影响的MGBRF，可以提高血糖指数（GI）的稳定性。
更新日期：2020-12-23
中文翻译：
环糊精糖基转移酶处理的发芽糙米粉可提高HepG2细胞的细胞毒性能力，并对2型糖尿病小鼠产生积极影响
发芽糙米（GBR）由对糖尿病治疗非常有用的生物活性化合物（BCs）组成。经过修饰的基于GBR的面粉（MGBRF）是通过用0、299.19、598.38和897.57 U / ml的环糊精糖基转移酶（CGTase）修饰GBR中的淀粉1小时后喷雾干燥以检查其抗糖尿病和细胞毒性作用而生产的。结果表明，用598.38 U / ml CGTase修饰GBR中的慢消化淀粉和抗性淀粉分别为55.8％和5.92％，分别与γ-氨基丁酸（GABA）和阿魏酸（FA）的增加有关。分别为4.31±0.68 mg / ml和3.10±0.02 mg / ml。MGBRF的提取物显示出对HepG2的强大细胞毒性能力。此外，体内研究显示，通过摄入对糖尿病有重大影响的MGBRF，可以提高血糖指数（GI）的稳定性。
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