Nanocomposite‐Based Matrices in Laser Desorption/Ionization Mass Spectrometry for Small‐Molecule Analysis,ChemPlusChem

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Nanocomposite‐Based Matrices in Laser Desorption/Ionization Mass Spectrometry for Small‐Molecule Analysis
ChemPlusChem ( IF 3.0 ) Pub Date : 2020-10-23 , DOI: 10.1002/cplu.202000619
Congcong Pei ₁ , Jingjing Wan ₁

Affiliation

The efficient detection of small molecules is of significance for environmental monitoring, pharmacology, metabolomics, and lipidomics. The laser desorption/ionization mass spectrometry (LDI MS) platform enables high sensitivity, accuracy, resolution, and throughput in molecular analysis, but its analytical capability with respect to small molecules is limited due to inherent drawbacks arising from conventional organic matrices. The selection of an appropriate matrix is thus a precondition for small molecule detection by LDI MS. To date, various inorganic matrices have been developed, with a growing interest in composite materials displaying synergetic effects. This Minireview highlights the development of nanocomposites as LDI matrices driven by numerous innovations in material science, and their emerging use in small‐molecule analysis.

中文翻译：

激光解吸/电离质谱中基于纳米复合材料的基质，用于小分子分析

小分子的有效检测对于环境监测，药理学，代谢组学和脂质组学具有重要意义。激光解吸/电离质谱（LDI MS）平台可实现分子分析的高灵敏度，准确性，分辨率和通量，但由于常规有机基质固有的缺陷，其对小分子的分析能力受到限制。因此，选择合适的基质是通过LDI MS检测小分子的前提。迄今为止，已经开发出各种无机基质，对显示协同作用的复合材料的兴趣日益浓厚。这份Minireview重点介绍了纳米复合材料作为LDI矩阵的发展，该矩阵是由材料科学中的众多创新驱动的，以及它们在小分子分析中的新兴应用。

更新日期：2020-11-06

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