Department of Biochemistry, Faculty of Science, Kasetsart University, Bangkok, 10900, Thailand.
Interdisciplinary Graduate Program in Bioscience, Faculty of Science, Kasetsart University, Bangkok, 10900, Thailand.
Department of Agricultural Sciences, Naresuan University, Phitsanlolok, 65000, Thailand.
Exploratory Research Center on Life and Living Systems (ExCELLS) and, Institute for Molecular Science (IMS), National Institutes of Natural Sciences, 5-1 Higashiyama, Myodaiji, 12 Okazaki, Aichi, 444-8787, Japan.
Department of Chemistry, Faculty of Science, Kasetsart University, 10900, Chatuchak, Bangkok, Thailand.
Center for Advanced Studies in Nanotechnology for Chemical, Food and Agricultural Industries, Kasetsart University, Bangkok, 10900, Thailand.
DNA aptamers are the new approach for anti‐HIV‐1 RT. These aptamers were isolated by the use of a DNA library complexed to WT HIV‐1 RT. The selected DNA aptamers showed an inhibitory effect on the polymerase reaction of HIV‐1 RTs (WT and KY mutant). NMR spectroscopy showed that the aptamer induced a conformational change in HIV‐1 RT′s structure.
中文翻译：
抗 HIV-1 逆转录酶的新 DNA 适体的表征
DNA 适配子是抗 HIV-1 RT 的新方法。这些适体是通过使用与 WT HIV-1 RT 复合的 DNA 文库来分离的。选定的 DNA 适配体对 HIV-1 RTs（WT 和 KY 突变体）的聚合酶反应显示出抑制作用。核磁共振波谱显示适体诱导了 HIV-1 RT 结构的构象变化。
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