A concatenation of study findings published during the last decade have brought into cold clarity the predominance and debilitating nature of depressive symptoms in adults with bipolar disorders (BD). For example, results from longitudinal, naturalistic studies in BD have concluded that for the majority of affected individuals, depressive symptoms manifest as “polarity first” and “polarity predominant” ¹. A separate body of literature indicates that the depressive symptoms of the adult with BD are the principal detractor of quality of life, mediator of psychosocial and workplace impairment, and identified by persons with life lived with BD as a priority therapeutic target.

中文翻译：

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体内表型研究，机制知情治疗，基于领域的精神病理学和法医学网络：双相抑郁症治疗发现和发展的策略

过去十年间发表的一系列研究结果使人们更加清楚地认识到双相情感障碍（BD）成人抑郁症状的普遍性和虚弱性。例如，来自BD的纵向自然研究的结果得出结论，对于大多数受影响的个体，抑郁症状表现为“两极优先”和“两极优势” ¹。另有文献表明，患有BD的成年人的抑郁症状是生活质量的主要降低因素，是社会心理和工作场所障碍的中介，并且被患有BD的生活者确定为优先治疗目标。