Ionization of amino acids (AA) is very important concept in biochemistry. We integrate the mathematical concept of probability with biochemically relevant process of AA ionization. We visualize the ionization process with Mathematica software discussing intramolecular interactions between weakly acidic/basic functional groups and charge-pH variation of amino acids in water solution. The visualizations rely on the notion of probability of ionization of functional groups and demonstrate how the extent of ionization and charge varies with pH of the solution. The examples described include amino acids and weak diprotic acids and bases. The aim is to help students better appreciate the importance and consequences of AA ionization and correct some misconceptions.

中文翻译：

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一个探索的想法：使用 Mathematica 可视化氨基酸的电离

氨基酸电离 (AA) 是生物化学中非常重要的概念。我们将概率的数学概念与 AA 电离的生化相关过程相结合。我们使用 Mathematica 软件可视化电离过程，讨论弱酸性/碱性官能团之间的分子内相互作用以及水溶液中氨基酸的电荷-pH 变化。可视化依赖于官能团电离概率的概念，并展示了电离和电荷的程度如何随溶液的 pH 值变化。所描述的例子包括氨基酸和弱二元酸和碱。目的是帮助学生更好地理解 AA 电离的重要性和后果，并纠正一些误解。