The oviduct is essential for reproduction. We previously showed that oviduct epithelial cells (OECs) isolated from aged cows expressed higher levels of inflammatory cytokines, including interleukin (IL) 1A and IL1B. In addition, aging is associated with tissue dysfunction and cellular senescence via a senescence‐associated secretory phenotype (SASP) and immune cell accumulation. We investigated whether IL1A or IL1B causes SASP production, cellular senescence, and inflammatory responses in bovine OECs.

中文翻译：

---

IL1B 触发牛输卵管上皮细胞中炎性细胞因子的产生并通过 CCL2 诱导中性粒细胞积累

输卵管对生殖至关重要。我们之前表明，从老年奶牛中分离的输卵管上皮细胞 (OEC) 表达更高水平的炎性细胞因子，包括白细胞介素 (IL) 1A 和 IL1B。此外，衰老通过衰老相关的分泌表型 (SASP) 和免疫细胞积累与组织功能障碍和细胞衰老有关。我们研究了 IL1A 或 IL1B 是否会导致牛 OEC 中的 SASP 产生、细胞衰老和炎症反应。