Role of Carbon Monoxide in Host–Gut Microbiome Communication,Chemical Reviews

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Role of Carbon Monoxide in Host–Gut Microbiome Communication
Chemical Reviews ( IF 51.4 ) Pub Date : 2020-10-22 , DOI: 10.1021/acs.chemrev.0c00586
Christopher P Hopper _{1,

2} , Ladie Kimberly De La Cruz ₃ , Kristin V Lyles ₄ , Lauren K Wareham ₅ , Jack A Gilbert ₆ , Zehava Eichenbaum ₄ , Marcin Magierowski ₇ , Robert K Poole ₈ , Jakob Wollborn _{9,

10} , Binghe Wang ₃

Affiliation

Institute for Experimental Biomedicine, University Hospital Wuerzburg, Wuerzburg, Bavaria DE 97080, Germany.
Department of Medicinal Chemistry, College of Pharmacy, The University of Florida, Gainesville, Florida 32611, United States.
Department of Chemistry & Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, Georgia 30303, United States.
Department of Biology, Georgia State University, Atlanta, Georgia 30303, United States.
The Vanderbilt Eye Institute and Department of Ophthalmology & Visual Sciences, The Vanderbilt University Medical Center and School of Medicine, Nashville, Tennessee 37232, United States.
Department of Pediatrics, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California 92093, United States.
Cellular Engineering and Isotope Diagnostics Laboratory, Department of Physiology, Jagiellonian University Medical College, Cracow PL 31-531, Poland.
Department of Molecular Biology and Biotechnology, The University of Sheffield, Firth Court, Sheffield S10 2TN, U.K.
Department of Anesthesiology and Critical Care, Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg DE 79085, Germany.
Department of Anesthesiology, Perioperative and Pain Management, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, United States.

Nature is full of examples of symbiotic relationships. The critical symbiotic relation between host and mutualistic bacteria is attracting increasing attention to the degree that the gut microbiome is proposed by some as a new organ system. The microbiome exerts its systemic effect through a diverse range of metabolites, which include gaseous molecules such as H₂, CO₂, NH₃, CH₄, NO, H₂S, and CO. In turn, the human host can influence the microbiome through these gaseous molecules as well in a reciprocal manner. Among these gaseous molecules, NO, H₂S, and CO occupy a special place because of their widely known physiological functions in the host and their overlap and similarity in both targets and functions. The roles that NO and H₂S play have been extensively examined by others. Herein, the roles of CO in host–gut microbiome communication are examined through a discussion of (1) host production and function of CO, (2) available CO donors as research tools, (3) CO production from diet and bacterial sources, (4) effect of CO on bacteria including CO sensing, and (5) gut microbiome production of CO. There is a large amount of literature suggesting the “messenger” role of CO in host–gut microbiome communication. However, much more work is needed to begin achieving a systematic understanding of this issue.

中文翻译：

一氧化碳在宿主-肠道微生物组通讯中的作用

大自然充满了共生关系的例子。宿主和互生细菌之间的关键共生关系正日益引起人们的注意，人们认为肠道微生物组是一种新的器官系统。微生物组通过多种代谢物发挥其系统作用，这些代谢物包括气态分子，例如H ₂，CO ₂，NH ₃，CH ₄，NO，H ₂ S和CO。反过来，人类宿主也会影响微生物组。通过这些气态分子相互交换。在这些气态分子中，NO，H ₂由于S和CO在宿主中具有广泛的生理功能，并且在目标和功能上都有重叠和相似性，因此它们占据了特殊的位置。NO和H ₂ S的作用已被其他人广泛研究。在此，通过讨论以下方面来研究CO在宿主-肠道微生物组通讯中的作用：（1）CO的宿主产生和功能；（2）作为研究工具的可用CO供体；（3）从饮食和细菌来源产生CO，（ 4）CO对细菌的影响，包括CO感测，以及（5）CO的肠道微生物组产生。大量文献表明，CO在宿主－肠道微生物组交流中起“信使”作用。但是，需要更多的工作来开始对这个问题有系统的理解。

更新日期：2020-12-23

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