Tracking the Biological Incorporation of Exogenous Molecules into Cellulose Fibers with Non‐Radioactive Iodinated Glucose,Israel Journal of Chemistry

当前位置： X-MOL 学术 › Isr. J. Chem. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Tracking the Biological Incorporation of Exogenous Molecules into Cellulose Fibers with Non‐Radioactive Iodinated Glucose
Israel Journal of Chemistry ( IF 2.3 ) Pub Date : 2020-10-21 , DOI: 10.1002/ijch.202000060
Filipe Natalio _{1,

2}

Affiliation

Semi‐synthetic biological fabrication explores biological systems and their biosynthetic pathways as inspiration for designing precursor analogs that can be metabolized in a similar manner as the natural substrates by organisms to yield new materials with tailored properties. Here we report the biological incorporation of a metabolizing iodinated glucose analog (2‐Deoxy‐2‐iodo‐D‐glucose, DIG) into Gossypium hirsutum cotton fibers in an ovule in‐vitro model. Structural modifications occur at the level of crystallite arrangement and compaction, with amorphization of the fibers and alteration of the H‐bond network between the cellulose nanofibrils. We further show that DIG can serve as a non‐radioactive micro computed tomography contrast agent (μCT). The fibers act as glucose sinks that accumulate DIG, enabling its detection by μCT. Quantitative analysis shows that the fibers are more oriented when incubated with DIG. This work demonstrates the advantages of using higher organisms for biological in‐situ transformation of economically important raw materials over conventional chemical surface modification processes, thereby providing a scientific foundation for implementing future alternatives and sustainable manufacturing strategies towards a bio‐based economy.

中文翻译：

使用非放射性碘化葡萄糖追踪外源分子在纤维素纤维中的生物掺入

半合成生物制造探索了生物系统及其生物合成途径，为设计前体类似物提供了灵感，这些类似物可以被生物体以与天然底物类似的方式代谢，从而产生具有定制特性的新材料。这里，我们报告的代谢碘化葡萄糖类似物（2-脱氧-2-碘- d葡萄糖，DIG）进入生物掺入陆地棉棉纤维在胚珠中的体外模型。结构的改变发生在微晶排列和压实的水平上，纤维的非晶化和纤维素纳米原纤维之间的氢键网络的改变。我们进一步证明DIG可以用作非放射性微计算机断层扫描造影剂（μCT）。纤维充当积累DIG的葡萄糖槽，从而可以通过μCT进行检测。定量分析表明，当与DIG孵育时，纤维的取向更强。这项工作证明了使用高级生物进行原位生物的优势通过传统的化学表面改性工艺对具有经济意义的原材料进行转化，从而为实施未来的替代方案和针对生物经济的可持续制造策略提供了科学基础。

更新日期：2020-12-14

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南11