Friend or enemy? Review of 17β‐HSD10 and its role in human health or disease

L. Vinklarova, M. Schmidt, O. Benek, K. Kuca, F. Gunn‐Moore and K. Musilek

17β‐hydroxysteroid dehydrogenase (17β‐HSD10) is a multifunctional human enzyme with important roles both as a structural component but also as a catalyst of many metabolic pathways. This mitochondrial enzyme has important functions in the metabolism, development and aging of the neural system, where it is involved in the homeostasis of neurosteroids, especially in regard to estradiol, changes in which make it an essential part of neurodegenerative pathology. In this review, 17β‐HSD10 role as a possible druggable target for neurodegenerative diseases including Alzheimer's disease is indicated, but it also has become apparent that it may have a role in hormone dependent cancer.

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中文翻译：

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发行信息

朋友还是敌人？17β-HSD10及其在人类健康或疾病中的作用的综述

L.Vinklarova，M.Schmidt，O.Benek，K.Kuca，F.Gunn-Moore和K.Musilek

17β-羟基类固醇脱氢酶（17β-HSD10）是一种多功能的人类酶，不仅作为结构成分而且在许多代谢途径中起着重要的作用。这种线粒体酶在神经系统的代谢，发育和衰老中具有重要的功能，参与神经甾体的稳态，尤其是与雌二醇有关，其变化使其成为神经变性病理学的重要组成部分。在这篇综述中，表明了17β-HSD10作为包括阿尔茨海默氏病在内的神经退行性疾病的可能药物靶标的作用，但也很明显它可能在激素依赖性癌症中起作用。

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