The balance between specificity and sensitivity in triage cytology must take into account that the first is the crucial point for the process of cervical cancer screening using HPV primary screening test. As the use of HPV as the primary screening test has completely changed the role of the Pap test in the screening algorithm, should “The Bethesda System for Reporting Cervical Cytology” be reviewed? In particular, is the use of the ASC‐US category still truly necessary?

中文翻译：

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在细胞学分类中是否仍然需要使用未确定意义类别的非典型鳞状细胞？

分流细胞学的特异性和敏感性之间的平衡必须考虑到，首先是使用HPV初筛试验进行宫颈癌筛查过程的关键点。由于使用 HPV 作为初步筛查试验已经完全改变了巴氏试验在筛查算法中的作用，是否应该审查“Bethesda 宫颈细胞学报告系统”？特别是，是否真的有必要使用 ASC-US 类别？