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Heterocyclic steroids: Synthetic routes and biological characteristics of steroidal fused bicyclic pyrimidines
Journal of Heterocyclic Chemistry ( IF 2.0 ) Pub Date : 2020-10-21 , DOI: 10.1002/jhet.4174
Khaled M. Elattar 1 , Ahmed El‐Mekabaty 1
Affiliation  

Natural steroids are characterized as a vital class of compounds, a type of secondary metabolites and components of cell membranes that widely accessible in plants or animals displayed significant pharmacological and varied biological properties. The present study aims to highlight the conveyed researches of synthetic routes adopted to obtain the various structures of steroidal fused bicyclic pyrimidines with substantial biological and pharmaceutical importance. The topic was discussed in light of the synthesis of fused [6 + 5] bicyclic systems, fused [6 + 6] bicyclic systems, binary heterocycles, and biological applications. In detail, the various synthetic strategies for the construction of steroids fused to bicyclic pyrazolopyrimidines, thiazolopyrimidines, triazolopyrimidines, pyridopyrimidines, pyranopyrimidines, and binary pyrimidines were discussed. Heterocyclic steroids of this class of compounds demonstrated potent anticancer, anti‐proliferative, anti‐neuro‐inflammatory, anti‐inflammatory, and anti‐ulcer activities. It was perceived that the synthetic steroids of such bicyclic pyrimidine scaffolds are fused into the steroid basic skeleton is essential for the potent bioactivities.

中文翻译:

杂环类固醇:甾族稠合双环嘧啶的合成途径和生物学特性

天然类固醇的特征是至关重要的一类化合物,是一类次生代谢产物和细胞膜的一种成分,在植物或动物中可广泛使用,并显示出重要的药理作用和多种生物学特性。本研究旨在突出对合成途径的研究,以取得具有重要生物学和药学重要性的甾族稠合双环嘧啶的各种结构。根据稠合的[6 + 5]双环系统,稠合的[6 + 6]双环系统,二元杂环和生物学应用的讨论,对该主题进行了讨论。详细地讲,构建与双环吡唑并嘧啶,噻唑并嘧啶,三唑并嘧啶,吡啶并嘧啶,吡喃并嘧啶融合的类固醇的各种合成策略,并讨论了二元嘧啶。这类化合物的杂环类固醇具有有效的抗癌,抗增殖,抗神经炎,抗炎和抗溃疡活性。人们认为,将这种双环嘧啶支架的合成类固醇融合到类固醇基本骨架中对于有效的生物活性是必不可少的。
更新日期:2020-10-21
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