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Tissue response to white mineral aggregate‐based cement containing barium sulfate as alternative radiopacifier: A randomized controlled animal study
Microscopy Research and Technique ( IF 2.0 ) Pub Date : 2020-10-21 , DOI: 10.1002/jemt.23629 Eduardo Antunes Bortoluzzi 1 , Cleonice da Silveira Teixeira 1 , Norberto J Broon 2 , Alberto Consolaro 3 , Tiago Novaes Pinheiro 4 , Lucas da Fonseca Roberti Garcia 1 , David H Pashley 5 , Clovis Monteiro Bramante 6
Microscopy Research and Technique ( IF 2.0 ) Pub Date : 2020-10-21 , DOI: 10.1002/jemt.23629 Eduardo Antunes Bortoluzzi 1 , Cleonice da Silveira Teixeira 1 , Norberto J Broon 2 , Alberto Consolaro 3 , Tiago Novaes Pinheiro 4 , Lucas da Fonseca Roberti Garcia 1 , David H Pashley 5 , Clovis Monteiro Bramante 6
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The purpose of this study was to investigate the tissue reaction stimulated by BaSO4‐ and Bi2O3‐containing White MTA Angelus, in comparison with Bi2O3‐containing white Portland cement, and white ProRoot MTA. Thirty‐six adult male Wistar rats (Rattus norvegicus), weighing between 250 and 300 g, were distributed into three groups (n = 12) in accordance with the period of sacrifice (15, 30, and 60 days). Four polyethylene tubes filled with the tested cements were implanted into the dorsum of each rat. Lateral wall of the tubes served as the negative control. After the experimental periods, the animals were euthanized by overdose of pentobarbital anesthetic solution, and the specimens were prepared for microscopic analysis under ×50, ×100, and ×400 magnifications. Inflammatory scores (0–3) were used to grade the tissue reaction. Data were analyzed by the Kruskal‐Wallis test and Dunn's test for individual comparisons (p < .05). A mild to moderate inflammatory tissue reaction was observed at the 15‐day period, which decreased over the course of the periods for all cements, except for Portland cement. There was no significant difference among the tissue responses for ProRoot MTA, BaSO4‐ and Bi2O3‐containing White MTA Angelus at the 60‐day period (p > .05). The Portland group had moderate inflammatory reaction at the final period of analysis, which was statistically different when compared to the other groups (p < .05). The microscopic findings of this animal study suggest that the addition of BaSO4 to White MTA Angelus does not hampers the biocompatibility of the cement.
中文翻译：
对含有硫酸钡的白色矿物骨料水泥作为替代不透辐射剂的组织反应：一项随机对照动物研究
本研究的目的是研究含 BaSO 4和 Bi 2 O 3的白色 MTA Angelus 所刺激的组织反应，并与含 Bi 2 O 3的白色波特兰水泥和白色 ProRoot MTA进行比较。36只成年雄性Wistar大鼠（Rattusnorvegicus ），体重250～300g，根据处死时间（15天、30天、60天）分为三组（n =12）。将四根装有测试水泥的聚乙烯管植入每只大鼠的背部。管的侧壁作为阴性对照。实验结束后，通过过量戊巴比妥麻醉溶液对动物实施安乐死，并制备标本在×50、×100和×400放大倍数下进行显微分析。炎症评分（0-3）用于对组织反应进行分级。通过 Kruskal-Wallis 检验和 Dunn 检验对数据进行分析以进行个体比较 ( p < .05)。在第 15 天期间观察到轻度至中度的炎症组织反应，除波特兰水泥外，所有水泥的炎症组织反应均随着时间的推移而减少。60 天期间，含有ProRoot MTA、BaSO 4和 Bi 2 O 3的 White MTA Angelus的组织反应没有显着差异( p > .05)。波特兰组在分析的最后阶段有中度炎症反应，与其他组相比有统计学差异 ( p < .05)。这项动物研究的微观结果表明，在 White MTA Angelus 中添加 BaSO 4不会影响水泥的生物相容性。
更新日期：2020-10-21
中文翻译：
对含有硫酸钡的白色矿物骨料水泥作为替代不透辐射剂的组织反应：一项随机对照动物研究
本研究的目的是研究含 BaSO 4和 Bi 2 O 3的白色 MTA Angelus 所刺激的组织反应，并与含 Bi 2 O 3的白色波特兰水泥和白色 ProRoot MTA进行比较。36只成年雄性Wistar大鼠（Rattusnorvegicus ），体重250～300g，根据处死时间（15天、30天、60天）分为三组（n =12）。将四根装有测试水泥的聚乙烯管植入每只大鼠的背部。管的侧壁作为阴性对照。实验结束后，通过过量戊巴比妥麻醉溶液对动物实施安乐死，并制备标本在×50、×100和×400放大倍数下进行显微分析。炎症评分（0-3）用于对组织反应进行分级。通过 Kruskal-Wallis 检验和 Dunn 检验对数据进行分析以进行个体比较 ( p < .05)。在第 15 天期间观察到轻度至中度的炎症组织反应，除波特兰水泥外，所有水泥的炎症组织反应均随着时间的推移而减少。60 天期间，含有ProRoot MTA、BaSO 4和 Bi 2 O 3的 White MTA Angelus的组织反应没有显着差异( p > .05)。波特兰组在分析的最后阶段有中度炎症反应，与其他组相比有统计学差异 ( p < .05)。这项动物研究的微观结果表明，在 White MTA Angelus 中添加 BaSO 4不会影响水泥的生物相容性。
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