Clinical features and antibody response of patients from a COVID‐19 treatment hospital in Wuhan, China,Journal of Medical Virology

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Clinical features and antibody response of patients from a COVID‐19 treatment hospital in Wuhan, China
Journal of Medical Virology ( IF 6.8 ) Pub Date : 2020-10-21 , DOI: 10.1002/jmv.26617
Yong Chen _{1,

2} , Yuehua Ke _{1,

2} , Xiong Liu _{1,

2} , Zhihua Wang _{1,

3} , Ruizhong Jia _{1,

2} , Wei Liu _{1,

2} , Chaojie Yang _{1,

2} , Leili Jia _{1,

2} , Yong Wang _{1,

2} , Li Han _{1,

2} , Xinyi Xia _{1,

4} , Sibing Zhang _{1,

5} , Changjun Wang _{1,

2}

Affiliation

Coronavirus disease 2019 (COVID‐19) has rapidly evolved into a global pandemic. A total of 1578 patients admitted into a newly built hospital specialized for COVID‐19 treatment in Wuhan, China, were enrolled. Clinical features and the levels of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) immunoglobulin (Ig)M and IgG were analyzed. In total, 1532 patients (97.2%) were identified as laboratory‐confirmed cases. Seventy‐seven patients were identified as asymptomatic carriers (n = 64) or SARS‐CoV‐2 RNA positive before symptom onset (n = 13). The positive rates of SARS‐CoV‐2 IgM and IgG were 80.4% and 96.8%, respectively. The median of IgM and IgG titers were 37.0A U/ml (interquartile range [IQR]: 13.4–81.1 AU/ml) and 156.9 AU/ml (IQR: 102.8–183.3 AU/ml), respectively. The IgM and IgG levels of asymptomatic patients (median titers, 8.3 AU/ml and 100.3 AU/ml) were much lower than those in symptomatic patients (median titers, 38.0 AU/ml and 158.2 AU/ml). A much lower IgG level was observed in critically ill patients 42–60 days after symptom onset. There were 153 patients with viral RNA shedding after IgG detection. These patients had a higher proportion of critical illness during hospitalization (p < .001) and a longer hospital stay (p < .001) compared to patients with viral clearance after IgG detection. Coronary heart disease (odds ratio [OR], 1.89 [95% confidence interval [CI], 1.11–3.24]; p = .020), and intensive care unit admission (OR, 2.47 [95% CI, 1.31–4.66]; p = .005) were independent risk factors associated with viral RNA shedding after IgG detection. Symptomatic patients produced more antibodies than asymptomatic patients. The patients who had SARS‐CoV‐2 RNA shedding after developing IgG were more likely to be sicker patients.

更新日期：2020-10-21

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