The use of resorbable devices for osteosynthesis has become a subject of interest. Nacre has been proposed as a resorbable and osteoconductive material favoring bone apposition without triggering an inflammatory reaction. We compared the in vivo osseointegration and erosion of nacre screws in an animal model with titanium screws. Implantation of similar nacre and titanium screws was performed in the femoral condyles of adult rats. Animals (n = 41) were randomized in four groups sacrificed at day one, 1, 6, and 12 months. Microcomputed tomography (microCT) allowed 3D morphometry of erosion of nacre. Osseointegration was measured as the volume of trabecular bone bone volume/tissue volume (BV/TV) in a standardized volume of interest around each screw. Undecalcified bone histology was also done. Gross examination revealed a similar clinical osseointegration for titanium and nacre screws. A progressive erosion of nacre screws, but no erosion of titanium screws, was observed in microCT. The volume of nacre screws progressively decreased over time whereas no modification occurred for titanium. For titanium screws, BV/TV remained stable throughout the study. For nacre screws, the BV/TV decrease was not statistically different. A significant difference was found between nacre and titanium screws at 6 months but not at 12 months. The screw heads, outside the bone shaft, were not eroded even after 12 months. Erosion of nacre occurred during the entire study period, only within the bone shaft in direct contact with bone marrow. Bone apposition was observed on nacre surfaces without signs of erosion. Nacre is a promising biomaterial in maxillofacial surgery.

中文翻译：

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动物模型中珍珠层螺钉的体内骨整合和侵蚀

使用可吸收装置进行接骨术已成为人们感兴趣的主题。珍珠层已被提议作为一种可吸收和骨传导材料，有利于骨附着而不会引发炎症反应。我们比较了动物模型中珍珠层螺钉与钛螺钉的体内骨整合和侵蚀情况。在成年大鼠的股骨髁中植入了类似的珍珠层和钛螺钉。动物（n = 41）被随机分为四组，分别在第 1、1、6 和 12 个月处死。微型计算机断层扫描 (microCT) 允许珍珠层侵蚀的 3D 形态测量。骨整合测量为每个螺钉周围标准化感兴趣体积中骨小梁骨体积/组织体积 (BV/TV) 的体积。还进行了未脱钙骨组织学检查。大体检查显示钛和珍珠层螺钉的临床骨整合相似。在 microCT 中观察到珍珠层螺钉逐渐腐蚀，但钛螺钉没有腐蚀。随着时间的推移，珍珠层螺钉的体积逐渐减少，而钛没有发生任何变化。对于钛螺钉，BV/TV 在整个研究过程中保持稳定。对于珍珠层螺钉，BV/TV 下降没有统计学差异。在 6 个月时发现珍珠层和钛螺钉之间存在显着差异，但在 12 个月时没有。即使在 12 个月后，骨干外的螺钉头也没有被侵蚀。在整个研究期间发生珍珠质侵蚀，仅在与骨髓直接接触的骨干内。在珍珠层表面上观察到骨沉积，没有侵蚀迹象。