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Metabolic mediators: How immunometabolism directs the immune response to infection
Immunology ( IF 4.9 ) Pub Date : 2020-10-21 , DOI: 10.1111/imm.13275
Eyal Amiel 1 , Georgia Perona-Wright 2
Affiliation  

Here we announce the first part of an exciting new series of reviews exploring the impact of immunometabolism in the interaction between host and pathogen, and in the outcome of infection. This collection discusses the links between metabolism and epigenetic control of cell function, post‐translation modifications of host proteins that determine protein fate and host cell function, the metabolic determinants of cell migration and immune cell activity, and the tussle for iron as a metabolic mediator of host‐pathogen domination. Together these reviews provide engaging new insight into the metabolic signals that guide the dynamic conversation between microbial pathogens and the mammalian hosts they aim to occupy.

中文翻译:

代谢介质:免疫代谢如何引导对感染的免疫反应

在这里,我们宣布了一系列令人兴奋的新综述的第一部分,探讨免疫代谢对宿主和病原体之间的相互作用以及感染结果的影响。该合集讨论了细胞功能的代谢和表观遗传控制之间的联系、决定蛋白质命运和宿主细胞功能的宿主蛋白的翻译后修饰、细胞迁移和免疫细胞活动的代谢决定因素,以及铁作为代谢介质的争论宿主病原体的控制。这些评论共同提供了对代谢信号的新见解,这些信号指导微生物病原体和它们想要占据的哺乳动物宿主之间的动态对话。
更新日期:2020-10-22
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