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Evaluating a novel MR‐compatible foot pedal device for unipedal and bipedal motion: Test–retest reliability of evoked brain activity
Human Brain Mapping ( IF 3.5 ) Pub Date : 2020-10-22 , DOI: 10.1002/hbm.25209 Jade D Doolittle 1 , Ryan J Downey 2, 3 , Julia P Imperatore 1 , Logan T Dowdle 4, 5 , Daniel H Lench 4 , John McLeod 1 , Daniel M McCalley 4 , Chris M Gregory 2 , Colleen A Hanlon 1, 6
Human Brain Mapping ( IF 3.5 ) Pub Date : 2020-10-22 , DOI: 10.1002/hbm.25209 Jade D Doolittle 1 , Ryan J Downey 2, 3 , Julia P Imperatore 1 , Logan T Dowdle 4, 5 , Daniel H Lench 4 , John McLeod 1 , Daniel M McCalley 4 , Chris M Gregory 2 , Colleen A Hanlon 1, 6
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The purpose of this study was to develop and evaluate a new, open‐source MR‐compatible device capable of assessing unipedal and bipedal lower extremity movement with minimal head motion and high test–retest reliability. To evaluate the prototype, 20 healthy adults participated in two magnetic resonance imaging (MRI) visits, separated by 2–6 months, in which they performed a visually guided dorsiflexion/plantar flexion task with their left foot, right foot, and alternating feet. Dependent measures included: evoked blood oxygen level‐dependent (BOLD) signal in the motor network, head movement associated with dorsiflexion/plantar flexion, the test–retest reliability of these measurements. Left and right unipedal movement led to a significant increase in BOLD signal compared to rest in the medial portion of the right and left primary motor cortex (respectively), and the ipsilateral cerebellum (FWE corrected, p < .001). Average head motion was 0.10 ± 0.02 mm. The test–retest reliability was high for the functional MRI data (intraclass correlation coefficients [ICCs]: >0.75) and the angular displacement of the ankle joint (ICC: 0.842). This bipedal device can robustly isolate activity in the motor network during alternating plantarflexion and dorsiflexion with minimal head movement, while providing high test–retest reliability. Ultimately, these data and open‐source building instructions will provide a new, economical tool for investigators interested in evaluating brain function resulting from lower extremity movement.
中文翻译：
评估用于单足和双足运动的新型 MR 兼容脚踏板装置：诱发大脑活动的测试-再测试可靠性
本研究的目的是开发和评估一种新的、开源的 MR 兼容设备，该设备能够以最小的头部运动和高重测可靠性评估单足和双足下肢运动。为了评估原型，20 名健康成年人参加了两次磁共振成像 (MRI) 访问，间隔 2-6 个月，他们用左脚、右脚和交替的脚执行视觉引导的背屈/跖屈任务。相关测量包括：运动网络中的诱发血氧水平相关 (BOLD) 信号、与背屈/跖屈相关的头部运动、这些测量的重测可靠性。p < .001）。平均头部运动为 0.10 ± 0.02 毫米。功能性 MRI 数据（组内相关系数 [ICC]：>0.75）和踝关节角位移（ICC：0.842）的重测信度很高。这种双足装置可以在交替的跖屈和背屈期间以最小的头部运动稳健地隔离运动网络中的活动，同时提供高的测试-再测试可靠性。最终，这些数据和开源构建说明将为有兴趣评估下肢运动导致的大脑功能的研究人员提供一种新的、经济的工具。
更新日期：2020-12-08
中文翻译：
评估用于单足和双足运动的新型 MR 兼容脚踏板装置：诱发大脑活动的测试-再测试可靠性
本研究的目的是开发和评估一种新的、开源的 MR 兼容设备，该设备能够以最小的头部运动和高重测可靠性评估单足和双足下肢运动。为了评估原型，20 名健康成年人参加了两次磁共振成像 (MRI) 访问，间隔 2-6 个月，他们用左脚、右脚和交替的脚执行视觉引导的背屈/跖屈任务。相关测量包括：运动网络中的诱发血氧水平相关 (BOLD) 信号、与背屈/跖屈相关的头部运动、这些测量的重测可靠性。p < .001）。平均头部运动为 0.10 ± 0.02 毫米。功能性 MRI 数据（组内相关系数 [ICC]：>0.75）和踝关节角位移（ICC：0.842）的重测信度很高。这种双足装置可以在交替的跖屈和背屈期间以最小的头部运动稳健地隔离运动网络中的活动，同时提供高的测试-再测试可靠性。最终，这些数据和开源构建说明将为有兴趣评估下肢运动导致的大脑功能的研究人员提供一种新的、经济的工具。
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