In mice, a tri‐layered (superficial, intermediate, and deep) vascular structure is formed in the retina during the third postnatal week. Short‐term treatment of newborn mice with vascular endothelial growth factor (VEGF) receptor inhibitors delays the formation of superficial vascular plexus and this allows us to investigate the developmental process of superficial and deep vascular plexuses at the same time. Using this model, we examined the effect of pharmacological depletion of retinal neurons on the formation of superficial and deep vascular plexuses.

中文翻译：

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视网膜神经元的药理耗竭可防止垂直血管生成，而不影响浅表血管丛


在小鼠中，出生后第三周，视网膜中形成三层（浅层、中间和深层）血管结构。用血管内皮生长因子（VEGF）受体抑制剂对新生小鼠进行短期治疗可延迟浅表血管丛的形成，这使我们能够同时研究浅表和深层血管丛的发育过程。使用该模型，我们检查了视网膜神经元的药理学耗竭对浅表和深层血管丛形成的影响。