INEXAS: A Phase 2 Randomised Trial of On‐Demand Inhaled Interferon Beta‐1a in Severe Asthmatics,Clinical & Experimental Allergy

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INEXAS: A Phase 2 Randomised Trial of On‐Demand Inhaled Interferon Beta‐1a in Severe Asthmatics
Clinical & Experimental Allergy ( IF 6.3 ) Pub Date : 2020-11-03 , DOI: 10.1111/cea.13765
Christopher McCrae _{1,

2} , Marita Olsson ₃ , Per Gustafson ₄ , Anna Malmgren ₅ , Malin Aurell ₆ , Malin Fagerås ₄ , Carla A Da Silva ₆ , Anders Cavallin ₇ , Jonathan Paraskos ₈ , Karin Karlsson ₇ , Cecilia Wingren ₁ , Phillip Monk ₉ , Richard Marsden ₉ , Tim Harrison ₁₀

Affiliation

Translational Science and Experimental Medicine, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, Maryland, USA.
Krefting Research Centre, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.
Early Biometrics and Statistical Innovation, Data Science and AI, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
BioPharmaceutical Medical, AstraZeneca, Gothenburg, Sweden.
Early Respiratory & Immunology Projects Department, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
Early Respiratory & Immunology Clinical Development, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
Translational Science and Experimental Medicine, Early Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
Point of Care Diagnostics, Precision Medicine, Oncology R&D, AstraZeneca, Cambridge, UK.
Synairgen Research Ltd, Southampton University Hospital, Southampton, UK.
Nottingham NIHR Biomedical Research Centre, University of Nottingham, Nottingham City Hospital, Nottingham, UK.

BACKGROUND Upper respiratory tract infections (URTI) are important triggers for asthma exacerbations. We hypothesised that inhalation of the anti-viral cytokine, interferon (IFN)-β, during URTI, could prevent these exacerbations.

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