Lipid accumulation, inflammatory responses and oxidative stress have been implicated in the pathology of alcohol‐induced liver injury (ALI). In this work, we evaluated the effects of the functional food XingJiuTang (XJT) on ALI and explored the underlying mechanism. We used alcohol‐stimulated human normal hepatocytes L02 for in vitro experiments, while for in vivo experiments, 55 % alcohol was intragastrically administrated to C57BL/6 mice at 16 mL/kg with pre‐administration of bifendate and XJT. Liver histology and function, along with the inflammatory cytokines, oxidative mediators and SIRT1/Nrf‐2 pathway were evaluated. The results showed that XJT treatment significantly alleviated ALI, ameliorated lipid peroxidation, improved the liver function impaired by alcohol and inhibited the hepatocytes apoptosis in vitro and in vivo. In addition, XJT treatment modulated the activation of the SIRT1/Nrf‐2 signaling pathway and suppressed the overexpression of NOX4. Overall, the functional food XJT effectively protects against experimental ALI via activating the SIRT1/Nrf‐2 pathway.

中文翻译：

---

功能性食品杏酒汤通过调节 SIRT1/Nrf-2 信号通路减轻酒精性肝损伤

脂质积累、炎症反应和氧化应激与酒精性肝损伤 (ALI) 的病理学有关。在这项工作中，我们评估了功能性食品杏酒汤（XJT）对 ALI 的影响并探索了其潜在机制。我们使用酒精刺激的人正常肝细胞 L02 进行体外实验，而在体内实验中，将 55% 的酒精以 16 mL/kg 的剂量给 C57BL/6 小鼠灌胃，并预先给予联苯双酯和 XJT。评估了肝脏组织学和功能，以及炎症细胞因子、氧化介质和 SIRT1/Nrf-2 通路。结果表明，XJT治疗显着减轻ALI，改善脂质过氧化，改善酒精损伤的肝功能，抑制体外和体内肝细胞凋亡。此外，XJT 治疗调节 SIRT1/Nrf-2 信号通路的激活并抑制 NOX4 的过度表达。总体而言，功能性食品 XJT 通过激活 SIRT1/Nrf-2 通路有效地预防实验性 ALI。