Synthesis of Multifunctional α,α‐Difluoroketones through Allylic Alkylation of Difluoroenoxysilanes with MBH Carbonates,Chemistry - An Asian Journal

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Synthesis of Multifunctional α,α‐Difluoroketones through Allylic Alkylation of Difluoroenoxysilanes with MBH Carbonates
Chemistry - An Asian Journal ( IF 3.5 ) Pub Date : 2020-10-21 , DOI: 10.1002/asia.202001145
Bo‐Wen Pan ₁ , Yang Shi ₁ , You‐Ping Tian ₁ , Ying Zhou ₁ , Jian Zhou _{1,

2,

3} , Jin‐Sheng Yu ₂

Affiliation

The first allylic alkylation of difluoroenoxysilanes with MBH carbonates catalyzed by triethylenediamine (DABCO) is developed, which allows rapid access to multifunctional α‐gem‐difluoroketones with up to 97% yields. Moreover, the gram‐scale synthesis and the diversifying transformation of products to valuable gem‐difluorinated molecules highlight the practicality of this methodology.

中文翻译：

二氟烯氧基硅烷与MBH碳酸酯的烯丙基烷基化反应合成多功能α，α-二氟酮

与MBH difluoroenoxysilanes的第一烯丙基烷基化的碳酸盐由三亚乙基二胺催化（DABCO）进行显影，其允许多官能快速访问α -宝石与高达97％的收率-difluoroketones。此外，克级合成和产品向有价值的宝石二氟化分子的多样化转化突出了该方法的实用性。

更新日期：2020-12-01

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