Genome Biology Unit, European Molecular Biology Laboratory, Meyerhofstraße 1, 69117, Heidelberg, Germany.
Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Schänzlestraße 18, 79104, Freiburg, Germany.
Faculty of Biology, University of Freiburg, Schänzlestraße 18, 79104, Freiburg, Germany.
Laboratory of Biosignaling and Therapeutics Department of Cellular and Molecular Medicine, KU Leuven, Herestraat 49, 3000, Leuven, Belgium.
Laboratory of Protein Phosphorylation and Proteomics Department of Cellular and Molecular Medicine, KU Leuven, Herestraat 49, 3000, Leuven, Belgium.
SyBioMa, KU Leuven, Herestraat 49, 3000, Leuven, Belgium.
Structural and Computational Biology Unit, European Molecular Biology Laboratory, Meyerhofstraße 1, 69117, Heidelberg, Germany.
Interrogating a mechanistic black box: Phosphoprotein phosphatase 1 (PP1) is among the major serine/threonine phosphatases and is involved in numerous pathways. Autoinhibition by phosphorylation of Thr320 at the C‐terminus leads to cell‐cycle arrest and neuronal defects. However, the mechanism underlying this regulatory phosphorylation site is unknown. Herein, we investigate potential mechanisms.
京公网安备 11010802027423号