Altered activity in the ventrolateral prefrontal and anterior cingulate cortices, as well as subcortical and amygdala projection sites, was previously reported during a first manic episode in youth with bipolar disorder and observed to be associated with treatment response. To extend these findings, we investigated functional connectivity among these regions in first-episode manic participants who remitted after 8 weeks of treatment compared to those who did not.

中文翻译：

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在第一次躁狂发作期间，前扣带回与杏仁核和尾状核的功能连接的变化区分了治疗后没有缓解的双相年轻成人

先前在患有双相情感障碍的青年的第一次躁狂发作期间报道了腹外侧前额叶和前扣带皮层以及皮质下和杏仁核投射部位的活动改变，并观察到与治疗反应有关。为了扩展这些发现，我们调查了治疗 8 周后缓解的首发躁狂参与者与未缓解的躁狂参与者的这些区域之间的功能连接性。