Assessment of clinicopathological and prognostic relevance of BMI-1 in patients with colorectal cancer: A meta-analysis,Biotechnology and Applied Biochemistry

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Assessment of clinicopathological and prognostic relevance of BMI-1 in patients with colorectal cancer: A meta-analysis
Biotechnology and Applied Biochemistry ( IF 3.2 ) Pub Date : 2020-10-21 , DOI: 10.1002/bab.2053
Mona Pourjafar _{1,

2} , Pouria Samadi _{1,

2} , Manoochehr Karami ₃ , Rezvan Najafi ₂

Affiliation

B-cell-specific Moloney leukemia virus insertion site 1 (BMI-1) is one of the stemness markers. The prognostic and clinicopathological effects of BMI-1 expression in colorectal cancer (CRC) have been in dispute with different studies. Eligible studies were retrieved from international databases up to December 2019. Studies with a relationship between the clinicopathological and prognostic value of CRC patients with BMI-1 expression were selected. The correlations in the random-effect model were evaluated using the hazard ratios, odds ratio, and 95% confidence intervals (CIs). A total of nine studies comprising Asian cases (seven studies) and European cases (two studies) covering 1,294 samples of CRC were included for this meta-analysis. The analysis suggested that in Asian cases, increased expression of BMI-1 was associated with poor overall survival (OS) and death-free survival, whereas in European populations, high expression of BMI-1 was associated with better OS. Also, overexpression of BMI-1 in the Asian population was associated with the tumor size, distant metastasis, and patient's gender and age. Results suggested that high expression of BMI-1 can be involved in the progression and invasion of CRC, and so its inhibitor-based therapies could be used to prevent the progression of CRC.

中文翻译：

评估 BMI-1 在结直肠癌患者中的临床病理学和预后相关性：一项荟萃分析

B 细胞特异性莫洛尼白血病病毒插入位点 1 (BMI-1) 是干性标记之一。不同研究对 BMI-1 表达在结直肠癌 (CRC) 中的预后和临床病理学影响存在争议。从截至 2019 年 12 月的国际数据库中检索了符合条件的研究。选择了具有 BMI-1 表达的 CRC 患者的临床病理学和预后价值之间关系的研究。使用风险比、优势比和 95% 置信区间 (CI) 评估随机效应模型中的相关性。这项荟萃分析共纳入了 9 项研究，包括亚洲病例（7 项研究）和欧洲病例（2 项研究），涵盖 1,294 个 CRC 样本。分析表明，在亚洲案例中，BMI-1 表达增加与较差的总生存期 (OS) 和无死亡生存期相关，而在欧洲人群中，BMI-1 的高表达与较好的 OS 相关。此外，亚洲人群中 BMI-1 的过度表达与肿瘤大小、远处转移以及患者的性别和年龄有关。结果表明，BMI-1的高表达可能参与CRC的进展和侵袭，因此其基于抑制剂的治疗可用于预防CRC的进展。

更新日期：2020-10-21

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