Novel IM‐associated protein Tim54 plays a role in the mitochondrial import of internal signal‐containing proteins in Trypanosoma brucei,Biology of the Cell

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Novel IM‐associated protein Tim54 plays a role in the mitochondrial import of internal signal‐containing proteins in Trypanosoma brucei
Biology of the Cell ( IF 2.4 ) Pub Date : 2020-11-09 , DOI: 10.1111/boc.202000054
Ujjal K Singha ₁ , Anuj Tripathi ₁ , Joseph T Smith ₁ , Linda Quinones ₁ , Aparajita Saha ₁ , Tanusree Singha ₁ , Minu Chaudhuri ₁

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The translocase of the mitochondrial inner membrane (TIM) imports most of the nucleus‐encoded proteins that are destined for the matrix, inner membrane (IM) and the intermembrane space (IMS). Trypanosoma brucei, the infectious agent for African trypanosomiasis, possesses a unique TIM complex consisting of several novel proteins in association with a relatively conserved protein TbTim17. Tandem affinity purification of the TbTim17 protein complex revealed TbTim54 as a potential component of this complex.

中文翻译：

新型 IM 相关蛋白 Tim54 在布氏锥虫内部信号蛋白的线粒体输入中发挥作用

线粒体内膜 (TIM) 的转位酶导入了大部分去往基质、内膜 (IM) 和膜间隙 (IMS) 的细胞核编码蛋白。布氏锥虫是非洲锥虫病的传染原，具有独特的 TIM 复合物，该复合物由与相对保守的蛋白质 TbTim17 相关的几种新型蛋白质组成。TbTim17 蛋白复合物的串联亲和纯化表明 TbTim54 是该复合物的潜在成分。

更新日期：2020-11-09

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