The COVID-19 Pandemic from a Human Genetic Perspective,Journal of Proteome Research

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The COVID-19 Pandemic from a Human Genetic Perspective
Journal of Proteome Research ( IF 3.8 ) Pub Date : 2020-10-21 , DOI: 10.1021/acs.jproteome.0c00671
Yue-Miao Zhang _{1,

2,

3} , Lin Wang ₄ , Xing-Zi Liu _{1,

2,

3} , Hong Zhang _{1,

2,

3}

Affiliation

The coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has impacted a large portion of the world population. From a virus genetic perspective, a recent study described what genomic data revealed about the origin and emergence of SARS-CoV-2, proposing stronger action against illegal wildlife trade. In the current “big data” era, an increasing number of large-scale, multidimensional omics data sets were publicly available. Herein, we review how human genetics tells us about the transmission, pathogenesis, susceptibility, severity, and drug prioritization of COVID-19. We further drafted a genetic roadmap of COVID-19, which was also expected to be applicable to other viruses with known receptors. Our review provides insights into the way of understanding a pandemic from a human genetic perspective.

中文翻译：

从人类基因角度看 COVID-19 大流行

2019 年冠状病毒病 (COVID-19) 由严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 引起，影响了世界很大一部分人口。从病毒遗传学的角度来看，最近的一项研究描述了基因组数据揭示的 SARS-CoV-2 的起源和出现，并建议采取更强有力的行动打击非法野生动物贸易。在当前的“大数据”时代，越来越多的大规模、多维组学数据集被公开。在此，我们回顾了人类遗传学如何告诉我们有关 COVID-19 的传播、发病机制、易感性、严重程度和药物优先顺序的信息。我们进一步起草了COVID-19的基因路线图，预计该路线图也适用于具有已知受体的其他病毒。我们的评论提供了从人类遗传学角度理解大流行的方式的见解。

更新日期：2020-11-06

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