Fabrication of Double-Network Hydrogels with Universal Adhesion and Superior Extensibility and Cytocompatibility by One-Pot Method,Biomacromolecules

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Fabrication of Double-Network Hydrogels with Universal Adhesion and Superior Extensibility and Cytocompatibility by One-Pot Method
Biomacromolecules ( IF 5.5 ) Pub Date : 2020-10-19 , DOI: 10.1021/acs.biomac.0c00822
Hui Sun ₁ , Min Zhang _{2,

3} , Meiling Liu ₁ , Yi Yu ₂ , Xinyuan Xu ₁ , Jianshu Li _{1,

2}

Affiliation

Hydrogels, which demand simultaneously tailorable mechanical properties and excellent biocompatibility, act as a promoting material for biomedical applications, e.g., tissue engineering scaffolds, wound dressing materials, and cartilage substitutes. Double-network hydrogels (DN hydrogels) have attracted widespread concerns due to their extraordinary mechanical strength and toughness, while traditional DN hydrogels are limited in terms of their biofunctionality. Based on the DN hydrogels composed of agar and acrylamide (AM), we incorporate vinylphosphoric acid (VPA) into the network to obtain agar/PAM/PVPA hydrogels with universal adhesion and superior cytocompatibility. Meanwhile, the agar/PAM/PVPA hydrogel maintains its high strength and toughness. It is noted that the elongation of the agar/PAM/PVPA hydrogel (molar ratio of VPA is 2%) is up to 3418.9 ± 54.9%. The cell experiment also demonstrates that the addition of VPA in a proper concentration can promote cell adhesion and proliferation. Furthermore, the hydrogel has the potential to be used as 3D printing and injectable materials because of the thermoreversible sol–gel agar. The reported agar/PAM/PVPA hydrogel in this work with universal adhesion, excellent mechanical properties, and excellent cytocompatibility is able to be used for biomedical applications as scaffolds, wound dressing materials, or cartilage repair materials.

中文翻译：

一锅法制备具有通用粘附性和优异的可扩展性和细胞相容性的双网络水凝胶

同时需要可调节的机械性能和出色的生物相容性的水凝胶可作为生物医学应用的促进材料，例如组织工程支架，伤口包扎材料和软骨替代物。双网状水凝胶（DN水凝胶）由于其非凡的机械强度和韧性而引起了广泛的关注，而传统的DN水凝胶的生物功能受到限制。基于由琼脂和丙烯酰胺（AM）组成的DN水凝胶，我们将乙烯基磷酸（VPA）掺入网络中，从而获得具有普遍附着力和优异细胞相容性的琼脂/ PAM / PVPA水凝胶。同时，琼脂/ PAM / PVPA水凝胶保持其高强度和韧性。注意到琼脂/ PAM / PVPA水凝胶的伸长率（VPA的摩尔比为2％）高达3418.9±54.9％。细胞实验还表明，以适当的浓度添加VPA可以促进细胞粘附和增殖。此外，由于热可逆的溶胶-凝胶琼脂，水凝胶有潜力用作3D打印和可注射材料。在这项工作中，已报道的琼脂/ PAM / PVPA水凝胶具有通用的附着力，优异的机械性能和出色的细胞相容性，可用于生物医学应用，如支架，伤口包扎材料或软骨修复材料。由于热可逆的溶胶-凝胶琼脂，水凝胶具有用作3D打印和可注射材料的潜力。在这项工作中，已报道的琼脂/ PAM / PVPA水凝胶具有通用的附着力，优异的机械性能和出色的细胞相容性，可用于生物医学应用，如支架，伤口包扎材料或软骨修复材料。由于热可逆的溶胶-凝胶琼脂，水凝胶有潜力用作3D打印和可注射材料。在这项工作中，已报道的琼脂/ PAM / PVPA水凝胶具有通用的附着力，优异的机械性能和出色的细胞相容性，可用于生物医学应用，如支架，伤口包扎材料或软骨修复材料。

更新日期：2020-12-14

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