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One-Step Protein–Polymer Conjugates from Boronic-Acid-Functionalized Polymers
Bioconjugate Chemistry ( IF 4.0 ) Pub Date : 2020-10-20 , DOI: 10.1021/acs.bioconjchem.0c00516
Michael J Swierczynski 1 , Zachary T Ball 1
Affiliation  

Polymer–protein conjugates are hybrid materials with interesting and useful properties. Methods to prepare diverse diblock materials of this sort often struggle to deal with the complexity and size of reagents, and so polymer–protein conjugation represents a stringent testing ground for nontraditional bioconjugation methods, such as metal-catalyzed arylation. This work demonstrates a simple Ni2+-promoted arylation of cysteine residues with end-functionalized polymer−boronic acid reagents, and explores some molecular and physical properties possible in these hybrid structures.

中文翻译:

一步法蛋白质聚合物与硼酸官能化聚合物结合。

聚合物-蛋白质结合物是具有有趣和有用特性的杂化材料。制备这种类型的多种二嵌段材料的方法通常难以应对试剂的复杂性和大小,因此聚合物-蛋白质偶联代表了非传统生物偶联方法(例如金属催化的芳基化)的严格测试基础。这项工作演示了一个简单的Ni 2+促进的半胱氨酸残基芳基化与末端官能化的聚合物硼酸试剂的芳基化反应,并探索了在这些杂化结构中可能的一些分子和物理性质。
更新日期:2020-11-18
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