Arc Plasma-Based Dissociation Device: Fingerprinting Mass Spectrometric Analysis Realized at Atmospheric Condition,Analytical Chemistry

当前位置： X-MOL 学术 › Anal. Chem. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Arc Plasma-Based Dissociation Device: Fingerprinting Mass Spectrometric Analysis Realized at Atmospheric Condition
Analytical Chemistry ( IF 6.7 ) Pub Date : 2020-10-21 , DOI: 10.1021/acs.analchem.0c03127
Su-zhen Zhu ₁ , Li Zhang ₁ , Jing Zhang ₁ , Yin-long Guo ₁

Affiliation

Fingerprinting mass spectrometric analysis at atmospheric conditions has been realized using an arc plasma-based dissociation (APD) device. Because of its high energy, high temperature, and unique chemical reactivity, the thermal plasma can induce dissociation of neutral molecules or ions produced by atmospheric ion sources. Both even/odd electron (fragment) ions would be generated to provide fingerprinting structural information and molecular weight of the compounds simultaneously. Meanwhile, elimination and aromatization were observed as special dissociation patterns in this device, which can be applied in the differentiation of isomers. The good compatibility with atmospheric ion sources is demonstrated by coupling the device with nanoelectrospray ionization (nano-ESI) and zero volt paper spray ionization (PSI), respectively. With erythromycin as the tuning standard, informative dissociation spectra of various compounds can be reproducible, making it possible to establish an arc plasma-based dissociation spectra database. This device allows fingerprinting mass spectrometric analysis, with no need for harsh vacuum conditions and is promising for making a breakthrough in making up the deficiency of atmospheric ionization techniques.

中文翻译：

基于电弧等离子体的解离装置：在大气条件下实现的指纹质谱分析

使用基于电弧等离子体的解离（APD）设备已经实现了大气条件下的指纹质谱分析。由于其高能量，高温和独特的化学反应性，热等离子体可以诱导中性分子或大气离子源产生的离子的离解。均会产生偶数/奇数电子（片段）离子，以同时提供指纹识别的结构信息和化合物的分子量。同时，在该装置中观察到消除和芳构化是特殊的解离模式，可用于异构体的区分。通过将该设备分别与纳米电喷雾电离（nano-ESI）和零伏纸喷雾电离（PSI）结合，证明了与大气离子源的良好兼容性。以红霉素为调整标准，可以再现各种化合物的信息解离光谱，从而可以建立基于电弧等离子体的解离光谱数据库。该设备可以进行指纹质谱分析，无需苛刻的真空条件，有望弥补大气电离技术的不足，取得突破。

更新日期：2020-11-03

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11