We report a particulate cell delivery platform, toroidal spiral particles (TSPs), for continuous cell activation, expansion, and local sustained release. Biocompatible TSPs, generated by a self-assembly process of polymeric droplet sedimentation in an aqueous solution and subsequent polymer solidification, possess many engineering design flexibilities to manipulate the microenvironment of the cells to control cell proliferation, migration, and release kinetics. These millimeter-size particles with desired mechanical and physicochemical properties may be potentially used for adoptive cellular therapy (ACT) delivery by a minimally invasive procedure to the tumor mass.

中文翻译：

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用于受控激活、增殖和递送的包裹人 T 细胞的异质聚合物颗粒

我们报告了一种用于连续细胞活化、扩增和局部持续释放的颗粒细胞递送平台、环形螺旋颗粒 (TSP)。生物相容性 TSP 是由聚合物液滴在水溶液中沉淀和随后的聚合物固化的自组装过程产生的，具有许多工程设计灵活性来操纵细胞的微环境以控制细胞增殖、迁移和释放动力学。这些具有所需机械和物理化学特性的毫米大小的颗粒可潜在地用于通过微创程序向肿瘤块递送过继细胞治疗 (ACT)。