Precise control of the activity and abundance of ubiquitin-conjugating enzymes (E2s) ensures fidelity in ubiquitin chain synthesis. In this issue of Science Signaling, Liess et al. demonstrate that the human anaphase-promoting complex (APC/C)–associated E2 UBE2S adopts an autoinhibited dimeric state that increases the half-life of UBE2S by preventing its autoubiquitination-driven turnover.

中文翻译：

---

紧紧拥抱：二聚化控制泛素结合酶UBE2S的更新

泛素结合酶（E2s）的活性和丰度的精确控制可确保泛素链合成的逼真度。在本期《科学信号》中，Liess等人。证明了与人后期促进复合物（APC / C）相关的E2 UBE2S采用一种自抑制二聚体状态，该状态通过阻止UBE2S自身泛素化驱动的更新来延长其半衰期。